Endothelial-smooth muscle cell interactions in the regulation of vascular tone in skeletal muscle.
The smooth muscle cells (SMCs) of skeletal muscle arterioles are intricately sensitive to changes in membrane potential. Upon increasing luminal pressure, the SMCs depolarize, thereby opening voltage-dependent Ca(2+) channels (VDCCs), which leads to contraction. Mechanisms that oppose this myogenic...
| Main Author: | |
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| Format: | Journal article |
| Language: | English |
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Wiley
2016
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| _version_ | 1797089625552977920 |
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| author | Dora, K |
| author_facet | Dora, K |
| author_sort | Dora, K |
| collection | OXFORD |
| description | The smooth muscle cells (SMCs) of skeletal muscle arterioles are intricately sensitive to changes in membrane potential. Upon increasing luminal pressure, the SMCs depolarize, thereby opening voltage-dependent Ca(2+) channels (VDCCs), which leads to contraction. Mechanisms that oppose this myogenic tone can involve voltage-dependent and independent dilator pathways, and can be endothelium-dependent or independent. Of particular interest are the pathways leading to hyperpolarization of SMCs, as these can potentially evoke both local and conducted dilation. This review focuses on three agonists that cause local and conducted dilation in skeletal muscle: acetylcholine (ACh), adenosine triphosphate (ATP) and KCl. The mechanisms for the release of these agonists during motor nerve stimulation and/or hypoxia, and their actions to open either Ca(2+) -activated K(+) channels (KC a ) or inwardly rectifying K(+) channels (KIR ) are described. By causing local and conducted dilation, each agonist has the ability to improve skeletal muscle blood flow during exercise and ischemia. This article is protected by copyright. All rights reserved. |
| first_indexed | 2024-03-07T03:06:44Z |
| format | Journal article |
| id | oxford-uuid:b2cd5026-5d33-4979-9fed-89654bee6365 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:06:44Z |
| publishDate | 2016 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:b2cd5026-5d33-4979-9fed-89654bee63652022-03-27T04:14:16ZEndothelial-smooth muscle cell interactions in the regulation of vascular tone in skeletal muscle.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b2cd5026-5d33-4979-9fed-89654bee6365EnglishSymplectic Elements at OxfordWiley2016Dora, KThe smooth muscle cells (SMCs) of skeletal muscle arterioles are intricately sensitive to changes in membrane potential. Upon increasing luminal pressure, the SMCs depolarize, thereby opening voltage-dependent Ca(2+) channels (VDCCs), which leads to contraction. Mechanisms that oppose this myogenic tone can involve voltage-dependent and independent dilator pathways, and can be endothelium-dependent or independent. Of particular interest are the pathways leading to hyperpolarization of SMCs, as these can potentially evoke both local and conducted dilation. This review focuses on three agonists that cause local and conducted dilation in skeletal muscle: acetylcholine (ACh), adenosine triphosphate (ATP) and KCl. The mechanisms for the release of these agonists during motor nerve stimulation and/or hypoxia, and their actions to open either Ca(2+) -activated K(+) channels (KC a ) or inwardly rectifying K(+) channels (KIR ) are described. By causing local and conducted dilation, each agonist has the ability to improve skeletal muscle blood flow during exercise and ischemia. This article is protected by copyright. All rights reserved. |
| spellingShingle | Dora, K Endothelial-smooth muscle cell interactions in the regulation of vascular tone in skeletal muscle. |
| title | Endothelial-smooth muscle cell interactions in the regulation of vascular tone in skeletal muscle. |
| title_full | Endothelial-smooth muscle cell interactions in the regulation of vascular tone in skeletal muscle. |
| title_fullStr | Endothelial-smooth muscle cell interactions in the regulation of vascular tone in skeletal muscle. |
| title_full_unstemmed | Endothelial-smooth muscle cell interactions in the regulation of vascular tone in skeletal muscle. |
| title_short | Endothelial-smooth muscle cell interactions in the regulation of vascular tone in skeletal muscle. |
| title_sort | endothelial smooth muscle cell interactions in the regulation of vascular tone in skeletal muscle |
| work_keys_str_mv | AT dorak endothelialsmoothmusclecellinteractionsintheregulationofvasculartoneinskeletalmuscle |