Coupling of Ca(2+) microdomains to spatially and temporally distinct cellular responses by the tyrosine kinase Syk.
Communication between the cell surface and the nucleus is essential for regulated gene expression. In neurons, Ca(2+)-dependent gene transcription is sensitive to local Ca(2+) entry. In immune cells, excitation-transcription coupling is thought to involve global Ca(2+) signals. Here, we show that in...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2009
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| _version_ | 1797089642731798528 |
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| author | Ng, S Nelson, C Parekh, A |
| author_facet | Ng, S Nelson, C Parekh, A |
| author_sort | Ng, S |
| collection | OXFORD |
| description | Communication between the cell surface and the nucleus is essential for regulated gene expression. In neurons, Ca(2+)-dependent gene transcription is sensitive to local Ca(2+) entry. In immune cells, excitation-transcription coupling is thought to involve global Ca(2+) signals. Here, we show that in mast cells, Ca(2+) microdomains from store-operated Ca(2+) release-activated Ca(2+) channels activate expression of the transcription factor c-fos. Local Ca(2+) entry is sensed by the tyrosine kinase Syk, which signals to the nucleus through the transcription factor STAT5. Ca(2+) microdomains also promote secretion of proinflammatory messengers, which, like gene expression, requires Syk. Syk therefore couples Ca(2+) microdomains to the activation of two spatially and temporally distinct cellular responses, revealing the versatility of local Ca(2+) signals in driving cell activation. |
| first_indexed | 2024-03-07T03:06:59Z |
| format | Journal article |
| id | oxford-uuid:b2e1bd8e-d2b4-4bd4-ae82-217d3ee6fcef |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:06:59Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:b2e1bd8e-d2b4-4bd4-ae82-217d3ee6fcef2022-03-27T04:14:55ZCoupling of Ca(2+) microdomains to spatially and temporally distinct cellular responses by the tyrosine kinase Syk.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b2e1bd8e-d2b4-4bd4-ae82-217d3ee6fcefEnglishSymplectic Elements at Oxford2009Ng, SNelson, CParekh, ACommunication between the cell surface and the nucleus is essential for regulated gene expression. In neurons, Ca(2+)-dependent gene transcription is sensitive to local Ca(2+) entry. In immune cells, excitation-transcription coupling is thought to involve global Ca(2+) signals. Here, we show that in mast cells, Ca(2+) microdomains from store-operated Ca(2+) release-activated Ca(2+) channels activate expression of the transcription factor c-fos. Local Ca(2+) entry is sensed by the tyrosine kinase Syk, which signals to the nucleus through the transcription factor STAT5. Ca(2+) microdomains also promote secretion of proinflammatory messengers, which, like gene expression, requires Syk. Syk therefore couples Ca(2+) microdomains to the activation of two spatially and temporally distinct cellular responses, revealing the versatility of local Ca(2+) signals in driving cell activation. |
| spellingShingle | Ng, S Nelson, C Parekh, A Coupling of Ca(2+) microdomains to spatially and temporally distinct cellular responses by the tyrosine kinase Syk. |
| title | Coupling of Ca(2+) microdomains to spatially and temporally distinct cellular responses by the tyrosine kinase Syk. |
| title_full | Coupling of Ca(2+) microdomains to spatially and temporally distinct cellular responses by the tyrosine kinase Syk. |
| title_fullStr | Coupling of Ca(2+) microdomains to spatially and temporally distinct cellular responses by the tyrosine kinase Syk. |
| title_full_unstemmed | Coupling of Ca(2+) microdomains to spatially and temporally distinct cellular responses by the tyrosine kinase Syk. |
| title_short | Coupling of Ca(2+) microdomains to spatially and temporally distinct cellular responses by the tyrosine kinase Syk. |
| title_sort | coupling of ca 2 microdomains to spatially and temporally distinct cellular responses by the tyrosine kinase syk |
| work_keys_str_mv | AT ngs couplingofca2microdomainstospatiallyandtemporallydistinctcellularresponsesbythetyrosinekinasesyk AT nelsonc couplingofca2microdomainstospatiallyandtemporallydistinctcellularresponsesbythetyrosinekinasesyk AT parekha couplingofca2microdomainstospatiallyandtemporallydistinctcellularresponsesbythetyrosinekinasesyk |