The South Asian genome
The genetic sequence variation of people from the Indian subcontinent who comprise one-quarter of the world's population, is not well described. We carried out whole genome sequencing of 168 South Asians, along with whole-exome sequencing of 147 South Asians to provide deeper characterisation o...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| 格式: | Journal article |
| 语言: | English |
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Public Library of Science
2014
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| _version_ | 1826291938069839872 |
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| author | Chambers, J Abbott, J Zhang, W Turro, E Scott, W Tan, S Afzal, U Afaq, S Loh, M Lehne, B O'Reilly, P Gaulton, K Pearson, R Li, X Lavery, A Vandrovcova, J Wass, M Miller, K Sehmi, J Oozageer, L Kooner, I Al-Hussaini, A Mills, R Grewal, J Panoulas, V Lewin, A Northwood, K Wander, G Geoghegan, F Li, Y Wang, J Aitman, T McCarthy, M Scott, J Butcher, S Elliott, P Kooner, J |
| author_facet | Chambers, J Abbott, J Zhang, W Turro, E Scott, W Tan, S Afzal, U Afaq, S Loh, M Lehne, B O'Reilly, P Gaulton, K Pearson, R Li, X Lavery, A Vandrovcova, J Wass, M Miller, K Sehmi, J Oozageer, L Kooner, I Al-Hussaini, A Mills, R Grewal, J Panoulas, V Lewin, A Northwood, K Wander, G Geoghegan, F Li, Y Wang, J Aitman, T McCarthy, M Scott, J Butcher, S Elliott, P Kooner, J |
| author_sort | Chambers, J |
| collection | OXFORD |
| description | The genetic sequence variation of people from the Indian subcontinent who comprise one-quarter of the world's population, is not well described. We carried out whole genome sequencing of 168 South Asians, along with whole-exome sequencing of 147 South Asians to provide deeper characterisation of coding regions. We identify 12,962,155 autosomal sequence variants, including 2,946,861 new SNPs and 312,738 novel indels. This catalogue of SNPs and indels amongst South Asians provides the first comprehensive map of genetic variation in this major human population, and reveals evidence for selective pressures on genes involved in skin biology, metabolism, infection and immunity. Our results will accelerate the search for the genetic variants underlying susceptibility to disorders such as type-2 diabetes and cardiovascular disease which are highly prevalent amongst South Asians. |
| first_indexed | 2024-03-07T03:07:01Z |
| format | Journal article |
| id | oxford-uuid:b2e39e5b-d0c1-41dd-a87d-ee365e0c583f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:07:01Z |
| publishDate | 2014 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:b2e39e5b-d0c1-41dd-a87d-ee365e0c583f2022-03-27T04:15:06ZThe South Asian genomeJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b2e39e5b-d0c1-41dd-a87d-ee365e0c583fEnglishSymplectic Elements at OxfordPublic Library of Science2014Chambers, JAbbott, JZhang, WTurro, EScott, WTan, SAfzal, UAfaq, SLoh, MLehne, BO'Reilly, PGaulton, KPearson, RLi, XLavery, AVandrovcova, JWass, MMiller, KSehmi, JOozageer, LKooner, IAl-Hussaini, AMills, RGrewal, JPanoulas, VLewin, ANorthwood, KWander, GGeoghegan, FLi, YWang, JAitman, TMcCarthy, MScott, JButcher, SElliott, PKooner, JThe genetic sequence variation of people from the Indian subcontinent who comprise one-quarter of the world's population, is not well described. We carried out whole genome sequencing of 168 South Asians, along with whole-exome sequencing of 147 South Asians to provide deeper characterisation of coding regions. We identify 12,962,155 autosomal sequence variants, including 2,946,861 new SNPs and 312,738 novel indels. This catalogue of SNPs and indels amongst South Asians provides the first comprehensive map of genetic variation in this major human population, and reveals evidence for selective pressures on genes involved in skin biology, metabolism, infection and immunity. Our results will accelerate the search for the genetic variants underlying susceptibility to disorders such as type-2 diabetes and cardiovascular disease which are highly prevalent amongst South Asians. |
| spellingShingle | Chambers, J Abbott, J Zhang, W Turro, E Scott, W Tan, S Afzal, U Afaq, S Loh, M Lehne, B O'Reilly, P Gaulton, K Pearson, R Li, X Lavery, A Vandrovcova, J Wass, M Miller, K Sehmi, J Oozageer, L Kooner, I Al-Hussaini, A Mills, R Grewal, J Panoulas, V Lewin, A Northwood, K Wander, G Geoghegan, F Li, Y Wang, J Aitman, T McCarthy, M Scott, J Butcher, S Elliott, P Kooner, J The South Asian genome |
| title | The South Asian genome |
| title_full | The South Asian genome |
| title_fullStr | The South Asian genome |
| title_full_unstemmed | The South Asian genome |
| title_short | The South Asian genome |
| title_sort | south asian genome |
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