Connectivity-based functional analysis of dopamine release in the striatum using diffusion-weighted MRI and positron emission tomography.

The striatum acts in conjunction with the cortex to control and execute functions that are impaired by abnormal dopamine neurotransmission in disorders such as Parkinson's and schizophrenia. To date, in vivo quantification of striatal dopamine has been restricted to structure-based striatal sub...

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Main Authors: Tziortzi, A, Haber, SN, Searle, G, Tsoumpas, C, Long, C, Shotbolt, P, Douaud, G, Jbabdi, S, Behrens, T, Rabiner, E, Jenkinson, M, Gunn, R
Format: Journal article
Language:English
Published: 2014
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author Tziortzi, A
Haber, SN
Searle, G
Tsoumpas, C
Long, C
Shotbolt, P
Douaud, G
Jbabdi, S
Behrens, T
Rabiner, E
Jenkinson, M
Gunn, R
author_facet Tziortzi, A
Haber, SN
Searle, G
Tsoumpas, C
Long, C
Shotbolt, P
Douaud, G
Jbabdi, S
Behrens, T
Rabiner, E
Jenkinson, M
Gunn, R
author_sort Tziortzi, A
collection OXFORD
description The striatum acts in conjunction with the cortex to control and execute functions that are impaired by abnormal dopamine neurotransmission in disorders such as Parkinson's and schizophrenia. To date, in vivo quantification of striatal dopamine has been restricted to structure-based striatal subdivisions. Here, we present a multimodal imaging approach that quantifies the endogenous dopamine release following the administration of d-amphetamine in the functional subdivisions of the striatum of healthy humans with [(11)C]PHNO and [(11)C]Raclopride positron emission tomography ligands. Using connectivity-based (CB) parcellation, we subdivided the striatum into functional subregions based on striato-cortical anatomical connectivity information derived from diffusion magnetic resonance imaging (MRI) and probabilistic tractography. Our parcellation showed that the functional organization of the striatum was spatially coherent across individuals, congruent with primate data and previous diffusion MRI studies, with distinctive and overlapping networks. d-amphetamine induced the highest dopamine release in the limbic followed by the sensory, motor, and executive areas. The data suggest that the relative regional proportions of D2-like receptors are unlikely to be responsible for this regional dopamine release pattern. Notably, the homogeneity of dopamine release was significantly higher within the CB functional subdivisions in comparison with the structural subdivisions. These results support an association between local levels of dopamine release and cortical connectivity fingerprints.
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spelling oxford-uuid:b2ebd7b5-d72a-4ec3-811a-55e2e646e9572022-03-27T04:15:14ZConnectivity-based functional analysis of dopamine release in the striatum using diffusion-weighted MRI and positron emission tomography.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b2ebd7b5-d72a-4ec3-811a-55e2e646e957EnglishSymplectic Elements at Oxford2014Tziortzi, AHaber, SNSearle, GTsoumpas, CLong, CShotbolt, PDouaud, GJbabdi, SBehrens, TRabiner, EJenkinson, MGunn, RThe striatum acts in conjunction with the cortex to control and execute functions that are impaired by abnormal dopamine neurotransmission in disorders such as Parkinson's and schizophrenia. To date, in vivo quantification of striatal dopamine has been restricted to structure-based striatal subdivisions. Here, we present a multimodal imaging approach that quantifies the endogenous dopamine release following the administration of d-amphetamine in the functional subdivisions of the striatum of healthy humans with [(11)C]PHNO and [(11)C]Raclopride positron emission tomography ligands. Using connectivity-based (CB) parcellation, we subdivided the striatum into functional subregions based on striato-cortical anatomical connectivity information derived from diffusion magnetic resonance imaging (MRI) and probabilistic tractography. Our parcellation showed that the functional organization of the striatum was spatially coherent across individuals, congruent with primate data and previous diffusion MRI studies, with distinctive and overlapping networks. d-amphetamine induced the highest dopamine release in the limbic followed by the sensory, motor, and executive areas. The data suggest that the relative regional proportions of D2-like receptors are unlikely to be responsible for this regional dopamine release pattern. Notably, the homogeneity of dopamine release was significantly higher within the CB functional subdivisions in comparison with the structural subdivisions. These results support an association between local levels of dopamine release and cortical connectivity fingerprints.
spellingShingle Tziortzi, A
Haber, SN
Searle, G
Tsoumpas, C
Long, C
Shotbolt, P
Douaud, G
Jbabdi, S
Behrens, T
Rabiner, E
Jenkinson, M
Gunn, R
Connectivity-based functional analysis of dopamine release in the striatum using diffusion-weighted MRI and positron emission tomography.
title Connectivity-based functional analysis of dopamine release in the striatum using diffusion-weighted MRI and positron emission tomography.
title_full Connectivity-based functional analysis of dopamine release in the striatum using diffusion-weighted MRI and positron emission tomography.
title_fullStr Connectivity-based functional analysis of dopamine release in the striatum using diffusion-weighted MRI and positron emission tomography.
title_full_unstemmed Connectivity-based functional analysis of dopamine release in the striatum using diffusion-weighted MRI and positron emission tomography.
title_short Connectivity-based functional analysis of dopamine release in the striatum using diffusion-weighted MRI and positron emission tomography.
title_sort connectivity based functional analysis of dopamine release in the striatum using diffusion weighted mri and positron emission tomography
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