The nemaline myopathy-causing E117K mutation in β-tropomyosin reduces thin filament activation.
The effect of the nemaline myopathy-causing E117K mutation in β-tropomyosin (TM) on the structure and function of this regulatory protein was studied. The E117K mutant was found to have indistinguishable actin affinity compared with wild-type (WT) and similar secondary structure as measured by circu...
Main Authors: | , , , , |
---|---|
格式: | Journal article |
語言: | English |
出版: |
2013
|