The nemaline myopathy-causing E117K mutation in β-tropomyosin reduces thin filament activation.
The effect of the nemaline myopathy-causing E117K mutation in β-tropomyosin (TM) on the structure and function of this regulatory protein was studied. The E117K mutant was found to have indistinguishable actin affinity compared with wild-type (WT) and similar secondary structure as measured by circu...
Main Authors: | , , , , |
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Format: | Journal article |
Language: | English |
Published: |
2013
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