The nemaline myopathy-causing E117K mutation in β-tropomyosin reduces thin filament activation.

The effect of the nemaline myopathy-causing E117K mutation in β-tropomyosin (TM) on the structure and function of this regulatory protein was studied. The E117K mutant was found to have indistinguishable actin affinity compared with wild-type (WT) and similar secondary structure as measured by circu...

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Main Authors: Karpicheva, O, Robinson, P, Piers, A, Borovikov, Y, Redwood, C
格式: Journal article
語言:English
出版: 2013