Atomic-resolution monitoring of protein maturation in live human cells by NMR

Atomic-resolution monitoring of protein maturation in live human cells by NMR

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We use NMR directly in live human cells to describe the complete post-translational maturation process of human superoxide dismutase 1 (SOD1). We follow, at atomic resolution, zinc binding, homodimer formation and copper uptake, and discover that copper chaperone for SOD1 oxidizes the SOD1 intrasubu...

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Bibliographic Details
Main Authors:	Banci, L, Barbieri, L, Bertini, I, Luchinat, E, Secci, E, Zhao, Y, Aricescu, A
Format:	Journal article
Language:	English
Published:	2013

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