Safety of the malaria vaccine candidate, RTS,S/AS01E in 5 to 17 month old Kenyan and Tanzanian Children.

Safety of the malaria vaccine candidate, RTS,S/AS01E in 5 to 17 month old Kenyan and Tanzanian Children.

The malaria vaccine candidate, RTS,S/AS01(E), showed promising protective efficacy in a trial of Kenyan and Tanzanian children aged 5 to 17 months. Here we report on the vaccine's safety and tolerability. The experimental design was a Phase 2b, two-centre, double-blind (observer- and participan...

Full description

Bibliographic Details
Main Authors:	Lusingu, J, Olotu, A, Leach, A, Lievens, M, Vekemans, J, Olivier, A, Benns, S, Olomi, R, Msham, S, Lang, T, Gould, J, Hallez, K, Guerra, Y, Njuguna, P, Awuondo, K, Malabeja, A, Abdul, O, Gesase, S, Dekker, D, Malle, L, Ismael, S, Mturi, N, Drakeley, C, Savarese, B, Villafana, T, Ballou, W, Cohen, J, Riley, E, Lemnge, M, Marsh, K, Bejon, P, von Seidlein, L
Format:	Journal article
Language:	English
Published:	Public Library of Science 2010

Similar Items

Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5-17 months in Kenya and Tanzania: a randomised controlled trial.
by: Olotu, A, et al.
Published: (2011)

Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5-17 months in Kenya and Tanzania: a randomised controlled trial
by: Olotu, A, et al.
Published: (2011)

Correction: Safety of the Malaria Vaccine Candidate, RTS,S/AS01 in 5 to 17 Month Old Kenyan and Tanzanian Children.
by: John Lusingu, et al.
Published: (2010-01-01)

Safety of the malaria vaccine candidate, RTS,S/AS01E in 5 to 17 month old Kenyan and Tanzanian Children.
by: John Lusingu, et al.
Published: (2010-11-01)

Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age.
by: Bejon, P, et al.
Published: (2008)

PHASE IIB, RANDOMIZED, DOUBLE-BLIND TRIAL TO ASSESS THE EFFICACY, SAFETY AND IMMUNOGENICITY OF THE CANDIDATE MALARIA VACCINE RTS,S/AS01 IN KENYAN AND TANZANIAN CHILDREN
by: Bejon, P, et al.
Published: (2008)

Effect of the pre-erythrocytic candidate malaria vaccine RTS,S/AS01E on blood stage immunity in young children.
by: Bejon, P, et al.
Published: (2011)

Four-year efficacy of RTS,S/AS01E and its interaction with malaria exposure.
by: Olotu, A, et al.
Published: (2013)

Circumsporozoite-specific T cell responses in children vaccinated with RTS,S/AS01E and protection against P falciparum clinical malaria.
by: Olotu, A, et al.
Published: (2011)

Antigen-specific IL-2 secretion correlates with NK cell responses after immunization of Tanzanian children with the RTS,S/AS01 malaria vaccine.
by: Horowitz, A, et al.
Published: (2012)

Avidity of anti-circumsporozoite antibodies following vaccination with RTS,S/AS01E in young children
by: Olotu, A, et al.
Published: (2014)

Serological evidence of discrete spatial clusters of Plasmodium falciparum parasites.
by: Bejon, P, et al.
Published: (2011)

Circumsporozoite-specific T cell responses in children vaccinated with RTS,S/AS01E and protection against P falciparum clinical malaria.
by: Ally Olotu, et al.
Published: (2011-01-01)

Design of a phase III multicenter trial to evaluate the efficacy of the RTS,S/AS01 malaria vaccine in children across diverse transmission settings in Africa
by: Macete Eusebio, et al.
Published: (2011-08-01)

RTS,S malaria vaccine efficacy and immunogenicity during Plasmodium falciparum challenge is associated with HLA genotype
by: Nielsen, C, et al.
Published: (2018)

Efficacy of RTS,S malaria vaccines: individual-participant pooled analysis of phase 2 data.
by: Bejon, P, et al.
Published: (2013)

Avidity of anti-circumsporozoite antibodies following vaccination with RTS,S/AS01E in young children.
by: Ally Olotu, et al.
Published: (2014-01-01)

Efficacy of RTS,S malaria vaccines: Individual-participant pooled analysis of phase 2 data
by: Bejon, P, et al.
Published: (2013)

Serological evidence of discrete spatial clusters of Plasmodium falciparum parasites.
by: Philip Bejon, et al.
Published: (2011-01-01)

Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care.
by: Vekemans, J, et al.
Published: (2011)

A randomized trial assessing the safety and immunogenicity of AS01 and AS02 adjuvanted RTS,S malaria vaccine candidates in children in Gabon.
by: Bertrand Lell, et al.
Published: (2009-10-01)

Development of standardized laboratory methods and quality processes for a phase III study of the RTS, S/AS01 candidate malaria vaccine
by: Carter Terrell, et al.
Published: (2011-08-01)

A seven-year study on the effect of the pre-erythrocytic malaria vaccine candidate RTS,S/AS01E on blood stage immunity in young Kenyan children
by: Ndungu, F, et al.
Published: (2019)

T cell responses to the RTS,S/AS01(E) and RTS,S/AS02(D) malaria candidate vaccines administered according to different schedules to Ghanaian children.
by: Daniel Ansong, et al.
Published: (2011-04-01)

Response to "Poor control vaccines in two randomised trials of malaria vaccine?".
by: Bejon, P, et al.
Published: (2009)

Seven year efficacy of RTS,S/AS01 malaria vaccine in young African children
by: Olotu, A, et al.
Published: (2016)

Safety profile of the RTS,S/AS01 malaria vaccine in infants and children: additional data from a phase III randomized controlled trial in sub-Saharan Africa
by: Guerra Mendoza, Y, et al.
Published: (2019)

A statistical interaction between circumsporozoite protein-specific T cell and antibody responses and risk of clinical malaria episodes following vaccination with RTS,S/AS01E
by: Ndungu, F, et al.
Published: (2012)

Further analysis of correlates of protection from a phase 2a trial of the falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults.
by: Olotu, A, et al.
Published: (2010)

A combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS,S malaria vaccine
by: White, M, et al.
Published: (2014)

Safety and immunogenicity of the RTS,S/AS01 malaria vaccine in infants and children identified as HIV-infected during a randomized trial in sub-Saharan Africa
by: Otieno, L, et al.
Published: (2019)

Impact of RTS,S/AS02(A) and RTS,S/AS01(B) on genotypes of P. falciparum in adults participating in a malaria vaccine clinical trial.
by: John N Waitumbi, et al.
Published: (2009-11-01)

Correction: Randomized Controlled Trial of RTS,S/AS02 and RTS,S/AS01 Malaria Candidate Vaccines Given According to Different Schedules in Ghanaian Children.
by: Seth Owusu-Agyei, et al.
Published: (2010-01-01)

Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/AS02(D).
by: Selidji T Agnandji, et al.
Published: (2011-04-01)

RTS,S/AS01E Vaccine against Malaria THE AUTHORS REPLY
by: Bejon, P, et al.
Published: (2009)

Randomized controlled trial of RTS,S/AS02D and RTS,S/AS01E malaria candidate vaccines given according to different schedules in Ghanaian children.
by: Seth Owusu-Agyei, et al.
Published: (2009-10-01)

Evaluation of RTS,S/AS02A and RTS,S/AS01B in adults in a high malaria transmission area.
by: Mark E Polhemus, et al.
Published: (2009-07-01)

Malaria host candidate genes validated by association with current, recent, and historical measures of transmission intensity
by: Sepúlveda, N, et al.
Published: (2017)

The future of the RTS,S/AS01 malaria vaccine: an alternative development plan
by: Gosling, R, et al.
Published: (2015)

The Future of the RTS,S/AS01 Malaria Vaccine: An Alternative Development Plan.
by: Roly Gosling, et al.
Published: (2016-04-01)