Blood stage antimalarial efficacy of primaquine in Plasmodium vivax malaria.
The blood stage antimalarial efficacy of primaquine (0.25 mg of base/kg of body weight/day over 14 days) and chloroquine (25 mg of base/kg over 3 days) were compared in 85 adult Thai men with acute Plasmodium vivax malaria. Most (75%) had at least one malaria episode previously. Parasite clearance t...
| Auteurs principaux: | , , , , |
|---|---|
| Format: | Journal article |
| Langue: | English |
| Publié: |
1994
|
| _version_ | 1826291984254369792 |
|---|---|
| author | Pukrittayakamee, S Vanijanonta, S Chantra, A Clemens, R White, N |
| author_facet | Pukrittayakamee, S Vanijanonta, S Chantra, A Clemens, R White, N |
| author_sort | Pukrittayakamee, S |
| collection | OXFORD |
| description | The blood stage antimalarial efficacy of primaquine (0.25 mg of base/kg of body weight/day over 14 days) and chloroquine (25 mg of base/kg over 3 days) were compared in 85 adult Thai men with acute Plasmodium vivax malaria. Most (75%) had at least one malaria episode previously. Parasite clearance times after primaquine alone (n = 30) were slower than after chloroquine (n = 30) or combined chloroquine-primaquine (n = 25), but all patients had a satisfactory initial therapeutic response. P. vivax malaria recurred in 10 (17%) of 60 patients followed for > or = 2 months and Plasmodium falciparum malaria developed in another 5 (8%) without reexposure to infection. Recurrences occurred < or = 5 weeks after primaquine treatment (n = 4), suggesting recrudescence, whereas recurrences after chloroquine treatment (n = 6) occurred > or = 5 weeks later, suggesting relapse. Vivax malaria responds well initially to either primaquine or chloroquine. The blood stage antimalarial activity of primaquine may mask chloroquine resistance in combined regimens. |
| first_indexed | 2024-03-07T03:07:43Z |
| format | Journal article |
| id | oxford-uuid:b31da9c5-3da2-408c-863a-8c00955be68d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:07:43Z |
| publishDate | 1994 |
| record_format | dspace |
| spelling | oxford-uuid:b31da9c5-3da2-408c-863a-8c00955be68d2022-03-27T04:16:44ZBlood stage antimalarial efficacy of primaquine in Plasmodium vivax malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b31da9c5-3da2-408c-863a-8c00955be68dEnglishSymplectic Elements at Oxford1994Pukrittayakamee, SVanijanonta, SChantra, AClemens, RWhite, NThe blood stage antimalarial efficacy of primaquine (0.25 mg of base/kg of body weight/day over 14 days) and chloroquine (25 mg of base/kg over 3 days) were compared in 85 adult Thai men with acute Plasmodium vivax malaria. Most (75%) had at least one malaria episode previously. Parasite clearance times after primaquine alone (n = 30) were slower than after chloroquine (n = 30) or combined chloroquine-primaquine (n = 25), but all patients had a satisfactory initial therapeutic response. P. vivax malaria recurred in 10 (17%) of 60 patients followed for > or = 2 months and Plasmodium falciparum malaria developed in another 5 (8%) without reexposure to infection. Recurrences occurred < or = 5 weeks after primaquine treatment (n = 4), suggesting recrudescence, whereas recurrences after chloroquine treatment (n = 6) occurred > or = 5 weeks later, suggesting relapse. Vivax malaria responds well initially to either primaquine or chloroquine. The blood stage antimalarial activity of primaquine may mask chloroquine resistance in combined regimens. |
| spellingShingle | Pukrittayakamee, S Vanijanonta, S Chantra, A Clemens, R White, N Blood stage antimalarial efficacy of primaquine in Plasmodium vivax malaria. |
| title | Blood stage antimalarial efficacy of primaquine in Plasmodium vivax malaria. |
| title_full | Blood stage antimalarial efficacy of primaquine in Plasmodium vivax malaria. |
| title_fullStr | Blood stage antimalarial efficacy of primaquine in Plasmodium vivax malaria. |
| title_full_unstemmed | Blood stage antimalarial efficacy of primaquine in Plasmodium vivax malaria. |
| title_short | Blood stage antimalarial efficacy of primaquine in Plasmodium vivax malaria. |
| title_sort | blood stage antimalarial efficacy of primaquine in plasmodium vivax malaria |
| work_keys_str_mv | AT pukrittayakamees bloodstageantimalarialefficacyofprimaquineinplasmodiumvivaxmalaria AT vanijanontas bloodstageantimalarialefficacyofprimaquineinplasmodiumvivaxmalaria AT chantraa bloodstageantimalarialefficacyofprimaquineinplasmodiumvivaxmalaria AT clemensr bloodstageantimalarialefficacyofprimaquineinplasmodiumvivaxmalaria AT whiten bloodstageantimalarialefficacyofprimaquineinplasmodiumvivaxmalaria |