An S/MAR-based infectious episomal genomic DNA expression vector provides long-term regulated functional complementation of LDLR deficiency

Episomal gene expression vectors offer a safe and attractive alternative to integrating vectors. Here we describe the development of a high capacity episomal vector system exploiting human episomal retention sequences to provide efficient vector maintenance and regulated gene expression through the...

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Autors principals: Lufino, M, Manservigi, R, Wade-Martins, R
Format: Journal article
Idioma:English
Publicat: Oxford University Press 2007
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