A scoping review of maternal antibiotic prophylaxis in low- and middle-income countries: comparison to WHO Recommendations regarding maternal peripartum infection
<p><strong>Background:</strong> Sepsis is a leading cause of maternal death. Antimicrobials save lives, but inappropriate overuse increases risk of antimicrobial resistance(AMR).</p> <p><strong>Objectives:</strong> A scoping review comparing peripartum prop...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Wiley
2021
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| _version_ | 1826292000300728320 |
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| author | Jury, I Thompson, K Hirst, J |
| author_facet | Jury, I Thompson, K Hirst, J |
| author_sort | Jury, I |
| collection | OXFORD |
| description | <p><strong>Background:</strong> Sepsis is a leading cause of maternal death. Antimicrobials save lives,
but inappropriate overuse increases risk of antimicrobial resistance(AMR).</p>
<p><strong>Objectives:</strong> A scoping review comparing peripartum prophylactic antimicrobial use in
low and middle-income countries(LMICs) with World Health Organization(WHO)
recommendations for prevention and treatment of maternal peripartum infection. Search strategy:Medline, Embase, Global Health, LILACS and the WHO Library
databases were searched. Selection criteria:Publications from LMICs since 2015 describing maternal prophlyactic antibiotics for Group B Streptococcus(GBS), preterm-prelabour rupture
of membranes(PPROM), caesarean section(CS), manual placental removal(MROP) and 3rd/4th degree perineal tears[1].</p>
<p><strong>Data collection and analysis:</strong> Publications were screened, and duplicates removed. A scoping review was conducted using PRISMA guidelines[9]. Owing to study
heterogeneity, a narrative synthesis was performed.</p>
<p><strong>Main results:</strong> Of 1886 studies, 27 met eligibility criteria from 13 countries involving 43,774 women. Polymerase Chain Reaction (PCR) screening for GBS is feasible, though limited financially. In PPROM, up to 42% of GBS isolates demonstrated erythromycin resistance[2]. Evidence around CS antimicrobial prophylaxis largely
supports WHO recommendations, however prolonged or multidrug regimes were reported.</p>
<p><strong>Conclusions:</strong> There is limited evidence to challenge current WHO recommendations to prevent peripartum infection in LMICs. However, implementation challenges exist. Given the emergence of AMR, research is needed to ensure peripartum prophylactic antimicrobial choices remain effective.</p> |
| first_indexed | 2024-03-07T03:07:57Z |
| format | Journal article |
| id | oxford-uuid:b3346273-ff99-44ef-b221-4fb921992d80 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:07:57Z |
| publishDate | 2021 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:b3346273-ff99-44ef-b221-4fb921992d802022-03-27T04:17:21ZA scoping review of maternal antibiotic prophylaxis in low- and middle-income countries: comparison to WHO Recommendations regarding maternal peripartum infectionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b3346273-ff99-44ef-b221-4fb921992d80EnglishSymplectic ElementsWiley2021Jury, IThompson, KHirst, J<p><strong>Background:</strong> Sepsis is a leading cause of maternal death. Antimicrobials save lives, but inappropriate overuse increases risk of antimicrobial resistance(AMR).</p> <p><strong>Objectives:</strong> A scoping review comparing peripartum prophylactic antimicrobial use in low and middle-income countries(LMICs) with World Health Organization(WHO) recommendations for prevention and treatment of maternal peripartum infection. Search strategy:Medline, Embase, Global Health, LILACS and the WHO Library databases were searched. Selection criteria:Publications from LMICs since 2015 describing maternal prophlyactic antibiotics for Group B Streptococcus(GBS), preterm-prelabour rupture of membranes(PPROM), caesarean section(CS), manual placental removal(MROP) and 3rd/4th degree perineal tears[1].</p> <p><strong>Data collection and analysis:</strong> Publications were screened, and duplicates removed. A scoping review was conducted using PRISMA guidelines[9]. Owing to study heterogeneity, a narrative synthesis was performed.</p> <p><strong>Main results:</strong> Of 1886 studies, 27 met eligibility criteria from 13 countries involving 43,774 women. Polymerase Chain Reaction (PCR) screening for GBS is feasible, though limited financially. In PPROM, up to 42% of GBS isolates demonstrated erythromycin resistance[2]. Evidence around CS antimicrobial prophylaxis largely supports WHO recommendations, however prolonged or multidrug regimes were reported.</p> <p><strong>Conclusions:</strong> There is limited evidence to challenge current WHO recommendations to prevent peripartum infection in LMICs. However, implementation challenges exist. Given the emergence of AMR, research is needed to ensure peripartum prophylactic antimicrobial choices remain effective.</p> |
| spellingShingle | Jury, I Thompson, K Hirst, J A scoping review of maternal antibiotic prophylaxis in low- and middle-income countries: comparison to WHO Recommendations regarding maternal peripartum infection |
| title | A scoping review of maternal antibiotic prophylaxis in low- and middle-income countries: comparison to WHO Recommendations regarding maternal peripartum infection |
| title_full | A scoping review of maternal antibiotic prophylaxis in low- and middle-income countries: comparison to WHO Recommendations regarding maternal peripartum infection |
| title_fullStr | A scoping review of maternal antibiotic prophylaxis in low- and middle-income countries: comparison to WHO Recommendations regarding maternal peripartum infection |
| title_full_unstemmed | A scoping review of maternal antibiotic prophylaxis in low- and middle-income countries: comparison to WHO Recommendations regarding maternal peripartum infection |
| title_short | A scoping review of maternal antibiotic prophylaxis in low- and middle-income countries: comparison to WHO Recommendations regarding maternal peripartum infection |
| title_sort | scoping review of maternal antibiotic prophylaxis in low and middle income countries comparison to who recommendations regarding maternal peripartum infection |
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