Elevated Myocardial Creatine Protects Against Ischemia/Reperfusion Injury by Improving Cardiac Energetics

Geahča maid

• Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction.
  Dahkki: Lygate, C, et al.
  Almmustuhtton: (2012)
• Ribose supplementation alone or with elevated creatine does not preserve high energy nucleotides or cardiac function in the failing mouse heart
  Dahkki: Faller, K, et al.
  Almmustuhtton: (2013)
• Living without creatine: Unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice
  Dahkki: Lygate, C, et al.
  Almmustuhtton: (2013)
• Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.
  Dahkki: Lygate, C, et al.
  Almmustuhtton: (2013)
• Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age
  Dahkki: Lygate, C, et al.
  Almmustuhtton: (2012)