Elevated Myocardial Creatine Protects Against Ischemia/Reperfusion Injury by Improving Cardiac Energetics

Elevated Myocardial Creatine Protects Against Ischemia/Reperfusion Injury by Improving Cardiac Energetics

Manylion Llyfryddiaeth
Prif Awduron:	Lygate, C, Bohl, S, ten Hove, M, Medway, D, Sebag-Montefiore, L, Zervou, S, Aksentijevic, D, Faller, K, Clarke, K, Watkins, H, Schneider, J, Neubauer, S
Fformat:	Conference item
Cyhoeddwyd:	2011

Eitemau Tebyg

Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction.
gan: Lygate, C, et al.
Cyhoeddwyd: (2012)

Ribose supplementation alone or with elevated creatine does not preserve high energy nucleotides or cardiac function in the failing mouse heart
gan: Faller, K, et al.
Cyhoeddwyd: (2013)

Living without creatine: Unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice
gan: Lygate, C, et al.
Cyhoeddwyd: (2013)

Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.
gan: Lygate, C, et al.
Cyhoeddwyd: (2013)

Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age
gan: Lygate, C, et al.
Cyhoeddwyd: (2012)

Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age.
gan: Lygate, C, et al.
Cyhoeddwyd: (2012)

Adaptations to Maintain Energy Homeostasis Compensate for Creatine-Deficiency in GAMT Knockout Mice Following Myocardial Infarction, but May Contribute to Early Mitochondrial Pathology During Aging
gan: Lygate, C, et al.
Cyhoeddwyd: (2011)

Ribose Supplementation Alone or with Elevated Creatine Does Not Preserve High Energy Nucleotides or Cardiac Function in the Failing Mouse Heart.
gan: Kiterie M E Faller, et al.
Cyhoeddwyd: (2013-01-01)

Chronic Creatine-deficiency is not the Underlying Cause of Cardiac Dysfunction in Mice Lacking the Creatine Biosynthetic Enzyme Arginine: glycine Amidinotransferase
gan: Lygate, C, et al.
Cyhoeddwyd: (2013)

A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis.
gan: Zervou, S, et al.
Cyhoeddwyd: (2013)

Regulation of Myocardial Creatine Uptake by Intra- and Extracellular Creatine Levels
gan: Makinen, K, et al.
Cyhoeddwyd: (2008)

REGULATION OF CELLULAR CREATINE HOMEOSTASIS: A ROLE FOR THIOREDOXIN INTERACTING PROTEIN (TXNIP)
gan: Zervou, S, et al.
Cyhoeddwyd: (2013)

Changes in creatine transporter function during cardiac maturation in the rat.
gan: Fischer, A, et al.
Cyhoeddwyd: (2010)

Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart
gan: Aksentijević, D, et al.
Cyhoeddwyd: (2014)

Hearts from gamt ko mice lack phospho-creatine, show reduced inotropic reserve and are more prone to ischemia
gan: ten Hove, M, et al.
Cyhoeddwyd: (2005)

Creatine uptake in mouse hearts with genetically altered creatine levels.
gan: ten Hove, M, et al.
Cyhoeddwyd: (2008)

Refined approach for quantification of in vivo ischemia-reperfusion injury in the mouse heart.
gan: Bohl, S, et al.
Cyhoeddwyd: (2009)

Creatine reduces mitochondrial permeability transition pore opening in response to oxidative stress in vitro
gan: Zervou, S, et al.
Cyhoeddwyd: (2010)

Regulation of myocardial creatine uptake capacity in genetically altered mouse models
gan: Ten Hove, M, et al.
Cyhoeddwyd: (2007)

High-energy phosphotransfer in the failing mouse heart: role of adenylate kinase and glycolytic enzymes.
gan: Aksentijević, D, et al.
Cyhoeddwyd: (2010)

Supernormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure - Insights from creatine transporter over-expression transgenic mice
gan: Wallis, J, et al.
Cyhoeddwyd: (2005)

The creatine kinase energy transport system in the failing mouse heart.
gan: Lygate, C, et al.
Cyhoeddwyd: (2007)

Supra-normal (phospho-)creatine levels lead to heart failure in mice overexpressing the cardiac creatine transporter - a longitudinal study
gan: ten Hove, M, et al.
Cyhoeddwyd: (2006)

Metabolic Inflexibility of Malonyl CoA Decarboxylase (MCD) Knockout Mice Leads to Cardiac Remodelling and High Mortality During Peri-Weaning Period
gan: Aksentijevic, D, et al.
Cyhoeddwyd: (2014)

Impaired cardiac contractile function in AGAT knockout mice devoid of creatine is rescued by homoarginine but not creatine
gan: Faller, K, et al.
Cyhoeddwyd: (2017)

Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic mice.
gan: Wallis, J, et al.
Cyhoeddwyd: (2005)

Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout mice.
gan: ten Hove, M, et al.
Cyhoeddwyd: (2005)

COMPENSATION FOR IMPAIRED MYOCARDIAL PHOSPHOTRANSFER IN GUANIDINOACETATE-N-METHYLTRANSFERASE KNOCKOUT MICE
gan: Aksentijevic, D, et al.
Cyhoeddwyd: (2010)

High energy phosphotransfer in the failing mouse heart-role of adenylate kinase and glycolytic enzymes
gan: Aksentijevic, D, et al.
Cyhoeddwyd: (2010)

Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity.
gan: Phillips, D, et al.
Cyhoeddwyd: (2010)

Guanidinoacetate N-methyltransferase-knockout mice completely lacking myocardial phosphocreatine show normal in vivo cardiac function, but increased susceptibility to ischemia/reperfusion injury
gan: Lygate, C, et al.
Cyhoeddwyd: (2004)

Complete absence of creatine but unaltered ATP levels in hearts from AGAT knockout mice
gan: ten Hove, M, et al.
Cyhoeddwyd: (2007)

The creatine kinase energy transport system in the failing mouse heart
gan: Lygate, C, et al.
Cyhoeddwyd: (2006)

Overexpression of mitochondrial creatine kinase preserves cardiac energetics without ameliorating murine chronic heart failure
gan: Cao, F, et al.
Cyhoeddwyd: (2020)

The creatine kinase system as a therapeutic target for myocardial ischaemia-reperfusion injury
gan: Cao, F, et al.
Cyhoeddwyd: (2018)

Cardiac phenotype of mitochondrial creatine kinase knockout mice is modified on a pure C57BL/6 genetic background.
gan: Lygate, C, et al.
Cyhoeddwyd: (2009)

Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart.
gan: Dunja Aksentijević, et al.
Cyhoeddwyd: (2014-01-01)

1H-MR spectroscopy for analysis of cardiac lipid and creatine metabolism
gan: Faller, K, et al.
Cyhoeddwyd: (2013)

(1)H-MR spectroscopy for analysis of cardiac lipid and creatine metabolism.
gan: Faller, K, et al.
Cyhoeddwyd: (2013)

Mechanisms of creatine depletion in chronically failing rat heart.
gan: Ten Hove, M, et al.
Cyhoeddwyd: (2005)