Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease.

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease.

Intracranial transplantation of neural stem cells (NSCs) delayed disease onset, preserved motor function, reduced pathology and prolonged survival in a mouse model of Sandhoff disease, a lethal gangliosidosis. Although donor-derived neurons were electrophysiologically active within chimeric regions,...

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Bibliographic Details
Main Authors: Lee, J, Jeyakumar, M, Gonzalez, R, Takahashi, H, Lee, P, Baek, R, Clark, D, Rose, H, Fu, G, Clarke, J, McKercher, S, Meerloo, J, Muller, F, Park, K, Butters, T, Dwek, R, Schwartz, P, Tong, G, Wenger, D, Lipton, SA, Seyfried, T, Platt, F, Snyder, E
Format: Journal article
Language:English
Published: 2007

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