Light and electron microscopical observations of the effects of high-density lipoprotein on growth of Plasmodium falciparum in vitro.
Human serum high-density lipoprotein (HDL) is necessary and sufficient for the short-term maintenance of Plasmodium falciparum in in vitro culture. However, at high concentrations it is toxic to the parasite. A heat-labile component is apparently responsible for the stage-specific toxicity to parasi...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2004
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| _version_ | 1797089731028189184 |
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| author | Imrie, H Ferguson, D Carter, M Drain, J Schiflett, A Hajduk, S Day, K |
| author_facet | Imrie, H Ferguson, D Carter, M Drain, J Schiflett, A Hajduk, S Day, K |
| author_sort | Imrie, H |
| collection | OXFORD |
| description | Human serum high-density lipoprotein (HDL) is necessary and sufficient for the short-term maintenance of Plasmodium falciparum in in vitro culture. However, at high concentrations it is toxic to the parasite. A heat-labile component is apparently responsible for the stage-specific toxicity to parasites within infected erythrocytes 12-42 h after invasion, i.e. during trophozoite maturation. The effects of HDL on parasite metabolism (as determined by nucleic acid synthesis) are evident at about 30 h after invasion. Parasites treated with HDL show gross abnormalities by light and electron microscopy. |
| first_indexed | 2024-03-07T03:08:17Z |
| format | Journal article |
| id | oxford-uuid:b34fb043-b8a8-4556-a571-932c02007dec |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:08:17Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:b34fb043-b8a8-4556-a571-932c02007dec2022-03-27T04:18:04ZLight and electron microscopical observations of the effects of high-density lipoprotein on growth of Plasmodium falciparum in vitro.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b34fb043-b8a8-4556-a571-932c02007decEnglishSymplectic Elements at Oxford2004Imrie, HFerguson, DCarter, MDrain, JSchiflett, AHajduk, SDay, KHuman serum high-density lipoprotein (HDL) is necessary and sufficient for the short-term maintenance of Plasmodium falciparum in in vitro culture. However, at high concentrations it is toxic to the parasite. A heat-labile component is apparently responsible for the stage-specific toxicity to parasites within infected erythrocytes 12-42 h after invasion, i.e. during trophozoite maturation. The effects of HDL on parasite metabolism (as determined by nucleic acid synthesis) are evident at about 30 h after invasion. Parasites treated with HDL show gross abnormalities by light and electron microscopy. |
| spellingShingle | Imrie, H Ferguson, D Carter, M Drain, J Schiflett, A Hajduk, S Day, K Light and electron microscopical observations of the effects of high-density lipoprotein on growth of Plasmodium falciparum in vitro. |
| title | Light and electron microscopical observations of the effects of high-density lipoprotein on growth of Plasmodium falciparum in vitro. |
| title_full | Light and electron microscopical observations of the effects of high-density lipoprotein on growth of Plasmodium falciparum in vitro. |
| title_fullStr | Light and electron microscopical observations of the effects of high-density lipoprotein on growth of Plasmodium falciparum in vitro. |
| title_full_unstemmed | Light and electron microscopical observations of the effects of high-density lipoprotein on growth of Plasmodium falciparum in vitro. |
| title_short | Light and electron microscopical observations of the effects of high-density lipoprotein on growth of Plasmodium falciparum in vitro. |
| title_sort | light and electron microscopical observations of the effects of high density lipoprotein on growth of plasmodium falciparum in vitro |
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