A touching case of channel regulation: the ATP-sensitive K+ channel.
The classical type of KATP channel is an octameric (4:4) complex of two structurally unrelated subunits, Kir6.2 and SUR. The former serves as an ATP-inhibitable pore, while SUR is a regulatory subunit endowing sensitivity to sulphonylurea and K+ channel opener drugs, and the potentiatory action of M...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1998
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| _version_ | 1797089735188938752 |
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| author | Tucker, S Ashcroft, F |
| author_facet | Tucker, S Ashcroft, F |
| author_sort | Tucker, S |
| collection | OXFORD |
| description | The classical type of KATP channel is an octameric (4:4) complex of two structurally unrelated subunits, Kir6.2 and SUR. The former serves as an ATP-inhibitable pore, while SUR is a regulatory subunit endowing sensitivity to sulphonylurea and K+ channel opener drugs, and the potentiatory action of MgADP. Both subunits are required to form a functional channel. |
| first_indexed | 2024-03-07T03:08:20Z |
| format | Journal article |
| id | oxford-uuid:b355b56f-433a-4607-b22b-956f02ed01a9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:08:20Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:b355b56f-433a-4607-b22b-956f02ed01a92022-03-27T04:18:12ZA touching case of channel regulation: the ATP-sensitive K+ channel.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b355b56f-433a-4607-b22b-956f02ed01a9EnglishSymplectic Elements at Oxford1998Tucker, SAshcroft, FThe classical type of KATP channel is an octameric (4:4) complex of two structurally unrelated subunits, Kir6.2 and SUR. The former serves as an ATP-inhibitable pore, while SUR is a regulatory subunit endowing sensitivity to sulphonylurea and K+ channel opener drugs, and the potentiatory action of MgADP. Both subunits are required to form a functional channel. |
| spellingShingle | Tucker, S Ashcroft, F A touching case of channel regulation: the ATP-sensitive K+ channel. |
| title | A touching case of channel regulation: the ATP-sensitive K+ channel. |
| title_full | A touching case of channel regulation: the ATP-sensitive K+ channel. |
| title_fullStr | A touching case of channel regulation: the ATP-sensitive K+ channel. |
| title_full_unstemmed | A touching case of channel regulation: the ATP-sensitive K+ channel. |
| title_short | A touching case of channel regulation: the ATP-sensitive K+ channel. |
| title_sort | touching case of channel regulation the atp sensitive k channel |
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