Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes.
Prostaglandin D2 (PGD2) is a lipid mediator produced by mast cells, macrophages and Th2 lymphocytes and has been detected in high concentrations in the airways of asthmatic patients. There are two receptors for PGD2, namely the D prostanoid (DP) receptor and the chemoattractant receptor-homologous m...
Những tác giả chính: | Gazi, L, Gyles, S, Rose, J, Lees, S, Allan, C, Xue, L, Jassal, R, Speight, G, Gamble, V, Pettipher, R |
---|---|
Định dạng: | Journal article |
Ngôn ngữ: | English |
Được phát hành: |
2005
|
Những quyển sách tương tự
-
Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2.
Bằng: Armer, R, et al.
Được phát hành: (2005) -
Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D(2).
Bằng: Xue, L, et al.
Được phát hành: (2007) -
A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatants.
Bằng: Gyles, S, et al.
Được phát hành: (2006) -
PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2.
Bằng: Schröder, R, et al.
Được phát hành: (2012) -
Prostaglandin D2 and Interleukin-5 Reduce Crth2 Surface Expression on Human Eosinophils
Bằng: Kazuyuki Hamada, et al.
Được phát hành: (2004-01-01)