Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes.
Prostaglandin D2 (PGD2) is a lipid mediator produced by mast cells, macrophages and Th2 lymphocytes and has been detected in high concentrations in the airways of asthmatic patients. There are two receptors for PGD2, namely the D prostanoid (DP) receptor and the chemoattractant receptor-homologous m...
मुख्य लेखकों: | Gazi, L, Gyles, S, Rose, J, Lees, S, Allan, C, Xue, L, Jassal, R, Speight, G, Gamble, V, Pettipher, R |
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स्वरूप: | Journal article |
भाषा: | English |
प्रकाशित: |
2005
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समान संसाधन
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Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2.
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प्रकाशित: (2005) -
Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D(2).
द्वारा: Xue, L, और अन्य
प्रकाशित: (2007) -
A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatants.
द्वारा: Gyles, S, और अन्य
प्रकाशित: (2006) -
PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2.
द्वारा: Schröder, R, और अन्य
प्रकाशित: (2012) -
Prostaglandin D2 and Interleukin-5 Reduce Crth2 Surface Expression on Human Eosinophils
द्वारा: Kazuyuki Hamada, और अन्य
प्रकाशित: (2004-01-01)