Efferocytosis of pathogen-infected cells
The prompt and efficient clearance of unwanted and abnormal cells by phagocytes is termed efferocytosis and is crucial for organism development, maintenance of tissue homeostasis, and regulation of the immune system. Dying cells are recognized by phagocytes through pathways initiated via "find...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Frontiers Media
2017
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| _version_ | 1826292030075043840 |
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| author | Karaji, N Sattentau, Q |
| author_facet | Karaji, N Sattentau, Q |
| author_sort | Karaji, N |
| collection | OXFORD |
| description | The prompt and efficient clearance of unwanted and abnormal cells by phagocytes is termed efferocytosis and is crucial for organism development, maintenance of tissue homeostasis, and regulation of the immune system. Dying cells are recognized by phagocytes through pathways initiated via "find me" signals, recognition via "eat me" signals and down-modulation of regulatory "don't eat me" signals. Pathogen infection may trigger cell death that drives phagocytic clearance in an immunologically silent, or pro-inflammatory manner, depending on the mode of cell death. In many cases, efferocytosis is a mechanism for eliminating pathogens and pathogen-infected cells; however, some pathogens have subverted this process and use efferocytic mechanisms to avoid innate immune detection and assist phagocyte infection. In parallel, phagocytes can integrate signals received from infected dying cells to elicit the most appropriate effector response against the infecting pathogen. This review focuses on pathogen-induced cell death signals that drive infected cell recognition and uptake by phagocytes, and the outcomes for the infected target cell, the phagocyte, the pathogen and the host. |
| first_indexed | 2024-03-07T03:08:25Z |
| format | Journal article |
| id | oxford-uuid:b35ca7af-51e5-4429-be60-45f464c47437 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:08:25Z |
| publishDate | 2017 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:b35ca7af-51e5-4429-be60-45f464c474372022-03-27T04:18:28ZEfferocytosis of pathogen-infected cellsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b35ca7af-51e5-4429-be60-45f464c47437EnglishSymplectic Elements at OxfordFrontiers Media2017Karaji, NSattentau, QThe prompt and efficient clearance of unwanted and abnormal cells by phagocytes is termed efferocytosis and is crucial for organism development, maintenance of tissue homeostasis, and regulation of the immune system. Dying cells are recognized by phagocytes through pathways initiated via "find me" signals, recognition via "eat me" signals and down-modulation of regulatory "don't eat me" signals. Pathogen infection may trigger cell death that drives phagocytic clearance in an immunologically silent, or pro-inflammatory manner, depending on the mode of cell death. In many cases, efferocytosis is a mechanism for eliminating pathogens and pathogen-infected cells; however, some pathogens have subverted this process and use efferocytic mechanisms to avoid innate immune detection and assist phagocyte infection. In parallel, phagocytes can integrate signals received from infected dying cells to elicit the most appropriate effector response against the infecting pathogen. This review focuses on pathogen-induced cell death signals that drive infected cell recognition and uptake by phagocytes, and the outcomes for the infected target cell, the phagocyte, the pathogen and the host. |
| spellingShingle | Karaji, N Sattentau, Q Efferocytosis of pathogen-infected cells |
| title | Efferocytosis of pathogen-infected cells |
| title_full | Efferocytosis of pathogen-infected cells |
| title_fullStr | Efferocytosis of pathogen-infected cells |
| title_full_unstemmed | Efferocytosis of pathogen-infected cells |
| title_short | Efferocytosis of pathogen-infected cells |
| title_sort | efferocytosis of pathogen infected cells |
| work_keys_str_mv | AT karajin efferocytosisofpathogeninfectedcells AT sattentauq efferocytosisofpathogeninfectedcells |