ATRX dysfunction induces replication defects in primary mouse cells

ATRX dysfunction induces replication defects in primary mouse cells

The chromatin remodeling protein ATRX, which targets tandem repetitive DNA, has been shown to be required for expression of the alpha globin genes, for proliferation of a variety of cellular progenitors, for chromosome congression and for the maintenance of telomeres. Mutations in ATRX have recently...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Clynes, D, Jelinska, C, Xella, B, Ayyub, H, Taylor, S, Mitson, M, Bachrati, C, Higgs, D, Gibbons, R
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	Public Library of Science 2014

Παρόμοια τεκμήρια

ATRX dysfunction induces replication defects in primary mouse cells.
ανά: David Clynes, κ.ά.
Έκδοση: (2014-01-01)

ATRX and the replication of structured DNA.
ανά: Clynes, D, κ.ά.
Έκδοση: (2013)

The chromatin remodeller ATRX: A repeat offender in human disease
ανά: Clynes, D, κ.ά.
Έκδοση: (2013)

The chromatin remodeller ATRX: a repeat offender in human disease.
ανά: Clynes, D, κ.ά.
Έκδοση: (2013)

Functional significance of mutations in the Snf2 domain of ATRX.
ανά: Mitson, M, κ.ά.
Έκδοση: (2011)

Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin.
ανά: Eustermann, S, κ.ά.
Έκδοση: (2011)

Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin
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Έκδοση: (2011)

Disruption of ATRX in mouse by conditional knockout.
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Έκδοση: (2002)

The chromatin remodelling factor ATRX suppresses R-loops in transcribed telomeric repeats
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Έκδοση: (2017)

ATRX: taming tandem repeats.
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Έκδοση: (2010)

Mutations in the chromatin-associated protein ATRX.
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Έκδοση: (2008)

XNP/ATRX at sites of nucleosome replacement.
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Έκδοση: (2009)

Identification of mutations in ATRX by RNase mismatch cleavage.
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Έκδοση: (1997)

Acquired somatic ATRX mutations in myelodysplastic syndrome associated with alpha thalassemia (ATMDS) convey a more severe hematologic phenotype than germline ATRX mutations.
ανά: Steensma, D, κ.ά.
Έκδοση: (2004)

Variant ATRX syndrome with dysfunction of ATRX and MAGT1 genes.
ανά: Qiao, Y, κ.ά.
Έκδοση: (2014)

ATRX targets variable number tandem repeats and thereby influences allele-specific expression
ανά: Lower, K, κ.ά.
Έκδοση: (2010)

Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation.
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Έκδοση: (2000)

Mutations in the human ATRX gene, encoding a putative transcription regulator, cause diverse changes in the pattern of DNA methylation.
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Έκδοση: (2000)

Identification of acquired somatic mutations in the chromatin remodelling factor ATRX in the a thalassaemia myelodysplasia syndrome (ATMDS)
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Έκδοση: (2003)

Identification of acquired somatic mutations in the chromatin remodelling factor ATRX in the alpha thalassemia myelodysplasia syndrome (ATMDS).
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Έκδοση: (2003)

Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX.
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Έκδοση: (2007)

Comparison of the human and murine ATRX gene identifies highly conserved, functionally important domains.
ανά: Picketts, D, κ.ά.
Έκδοση: (1998)

Identification of acquired somatic mutations in the gene encoding chromatin-remodeling factor ATRX in the alpha-thalassemia myelodysplasia syndrome (ATMDS).
ανά: Gibbons, R, κ.ά.
Έκδοση: (2003)

alpha-thalassaemia, X-linked mental retardation syndrome protein, ATRX, interacts with ribosomal genes.
ανά: Law, M, κ.ά.
Έκδοση: (2003)

Acquired alpha-thalassaernia in association with myelodysplastic syndrome (ATMDS): Two further private ATRX mutations
ανά: Fisher, C, κ.ά.
Έκδοση: (2007)

A novel mutation in the last exon of ATRX in a patient with alpha-thalassemia myelodysplastic syndrome.
ανά: Costa, D, κ.ά.
Έκδοση: (2006)

How to tackle challenging ChIP-Seq, with long-range cross-linking, using ATRX as an example
ανά: Truch, J, κ.ά.
Έκδοση: (2018)

A nonsense mutation of the ATRX gene causing mild mental retardation and epilepsy.
ανά: Guerrini, R, κ.ά.
Έκδοση: (2000)

DHPLC analysis of the ATRX gene in myelodysplastic syndrome (MDS) associated with acquired alpha thalassemia (AT-MDS): Novel mutation detection despite somatic mosaicism.
ανά: Steensma, D, κ.ά.
Έκδοση: (2003)

The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis.
ανά: Bérubé, N, κ.ά.
Έκδοση: (2005)

A novel splicing mutation in the gene encoding the chromatin-associated factor ATRX associated with acquired hemoglobin H disease in myelodysplastic syndrome (ATMDS)
ανά: Steensma, D, κ.ά.
Έκδοση: (2004)

Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues.
ανά: Garrick, D, κ.ά.
Έκδοση: (2006)

Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues.
ανά: Garrick, D, κ.ά.
Έκδοση: (2006)

Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53.
ανά: Seah, C, κ.ά.
Έκδοση: (2008)

The loss of ATRX increases susceptibility to pancreatic injury and oncogenic KRAS in female but not male mice
ανά: Young, C, κ.ά.
Έκδοση: (2018)

Phosphorylation of ‘SDT-like’ motifs in ATRX mediates its interaction with the MRN complex and is important for ALT pathway suppression
ανά: Tomas Goncalves, κ.ά.
Έκδοση: (2024-12-01)

Two novel somatic mutations of the ATRX gene in female patients with acquired alpha thalassemia of myelodysplastic syndrome (ATMDS).
ανά: Haas, P, κ.ά.
Έκδοση: (2006)

Mutant ATRX: pathogenesis of ATRX syndrome and cancer
ανά: Kejia Yuan, κ.ά.
Έκδοση: (2024-10-01)

Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers
ανά: Goncalves, T, κ.ά.
Έκδοση: (2025)

ATRX encodes a novel member of the SNF2 family of proteins: mutations point to a common mechanism underlying the ATR-X syndrome.
ανά: Picketts, D, κ.ά.
Έκδοση: (1996)