ATRX dysfunction induces replication defects in primary mouse cells

The chromatin remodeling protein ATRX, which targets tandem repetitive DNA, has been shown to be required for expression of the alpha globin genes, for proliferation of a variety of cellular progenitors, for chromosome congression and for the maintenance of telomeres. Mutations in ATRX have recently...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Clynes, D, Jelinska, C, Xella, B, Ayyub, H, Taylor, S, Mitson, M, Bachrati, C, Higgs, D, Gibbons, R
Format: Journal article
Sprache:English
Veröffentlicht: Public Library of Science 2014