Mutations of phenylalanine-193 in the putative substrate access channel alter the substrate specificity of cytochrome P450(cam)
The Phe-193 residue on the surface of cytochrome P450cam is part of a cluster of residues proposed to undergo dynamic fluctuations to permit the entry of substrates into the active site pocket. The role of this residue in the activity of P450cam has been investigated. The F193A, F193V, F193I, and F1...
| मुख्य लेखकों: | , , |
|---|---|
| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
2000
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