Transcription-dependent DNA double-strand breaks and human disease
Accumulation of DNA damage in resting cells is an emerging cause of human disease. We identified a mechanism of DNA double-strand break (DSB) formation in non-replicating cells, which strictly depends on transcription. These transcriptional DSBs arise from the twinned processing of R-loops and topoi...
| Huvudupphovsmän: | , , |
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| Materialtyp: | Journal article |
| Språk: | English |
| Publicerad: |
Taylor and Francis
2020
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| _version_ | 1826292113946443776 |
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| author | Cristini, A Gromak, N Sordet, O |
| author_facet | Cristini, A Gromak, N Sordet, O |
| author_sort | Cristini, A |
| collection | OXFORD |
| description | Accumulation of DNA damage in resting cells is an emerging cause of human disease. We identified a mechanism of DNA double-strand break (DSB) formation in non-replicating cells, which strictly depends on transcription. These transcriptional DSBs arise from the twinned processing of R-loops and topoisomerase I and may underlie neurological disorders and cancers. |
| first_indexed | 2024-03-07T03:09:42Z |
| format | Journal article |
| id | oxford-uuid:b3c3334a-f86f-41e9-87b7-4b7e500fb64c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:09:42Z |
| publishDate | 2020 |
| publisher | Taylor and Francis |
| record_format | dspace |
| spelling | oxford-uuid:b3c3334a-f86f-41e9-87b7-4b7e500fb64c2022-03-27T04:21:33ZTranscription-dependent DNA double-strand breaks and human diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b3c3334a-f86f-41e9-87b7-4b7e500fb64cEnglishSymplectic ElementsTaylor and Francis2020Cristini, AGromak, NSordet, OAccumulation of DNA damage in resting cells is an emerging cause of human disease. We identified a mechanism of DNA double-strand break (DSB) formation in non-replicating cells, which strictly depends on transcription. These transcriptional DSBs arise from the twinned processing of R-loops and topoisomerase I and may underlie neurological disorders and cancers. |
| spellingShingle | Cristini, A Gromak, N Sordet, O Transcription-dependent DNA double-strand breaks and human disease |
| title | Transcription-dependent DNA double-strand breaks and human disease |
| title_full | Transcription-dependent DNA double-strand breaks and human disease |
| title_fullStr | Transcription-dependent DNA double-strand breaks and human disease |
| title_full_unstemmed | Transcription-dependent DNA double-strand breaks and human disease |
| title_short | Transcription-dependent DNA double-strand breaks and human disease |
| title_sort | transcription dependent dna double strand breaks and human disease |
| work_keys_str_mv | AT cristinia transcriptiondependentdnadoublestrandbreaksandhumandisease AT gromakn transcriptiondependentdnadoublestrandbreaksandhumandisease AT sordeto transcriptiondependentdnadoublestrandbreaksandhumandisease |