Transcription-dependent DNA double-strand breaks and human disease

Accumulation of DNA damage in resting cells is an emerging cause of human disease. We identified a mechanism of DNA double-strand break (DSB) formation in non-replicating cells, which strictly depends on transcription. These transcriptional DSBs arise from the twinned processing of R-loops and topoi...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Cristini, A, Gromak, N, Sordet, O
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: Taylor and Francis 2020