Intercenter agreement of brain atrophy measurement in multiple sclerosis patients using manually-edited SIENA and SIENAX.
PURPOSE: To investigate intercenter agreement of brain volume (change) measurement in multiple sclerosis (MS) using structural image evaluation using normalization of atrophy (SIENA) and the cross-sectional version of SIENA (SIENAX) with additional manual editing to correct for inadequate brain ext...
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Sprache: | English |
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2007
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| _version_ | 1826292126056448000 |
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| author | Jasperse, B Valsasina, P Neacsu, V Knol, D De Stefano, N Enzinger, C Smith, S Ropele, S Korteweg, T Giorgio, A Anderson, V Polman, C Filippi, M Miller, D Rovaris, M Barkhof, F Vrenken, H |
| author_facet | Jasperse, B Valsasina, P Neacsu, V Knol, D De Stefano, N Enzinger, C Smith, S Ropele, S Korteweg, T Giorgio, A Anderson, V Polman, C Filippi, M Miller, D Rovaris, M Barkhof, F Vrenken, H |
| author_sort | Jasperse, B |
| collection | OXFORD |
| description | PURPOSE: To investigate intercenter agreement of brain volume (change) measurement in multiple sclerosis (MS) using structural image evaluation using normalization of atrophy (SIENA) and the cross-sectional version of SIENA (SIENAX) with additional manual editing to correct for inadequate brain extraction. MATERIALS AND METHODS: Baseline and follow-up T1-weighted MR images of 20 MS patients were dispatched to five centers. Each center performed fully-automated and manually-edited analyses for SIENAX, yielding normalized brain volume (NBV), and SIENA, yielding percentage brain volume change (PBVC). Intercenter agreement was assessed with the concordance correlation coefficient (CCC). RESULTS: Intercenter agreement was perfect for fully automated NBV and PBVC (both CCC = 1.0), and remained substantial upon manual editing (CCC = 0.94 for NBV, CCC = 0.95 for PBVC). Mean NBV values for each center decreased significantly after manual editing (overall mean NBV = 1605.3 cm(3) vs. 1651.1 cm(3) without manual editing; t = -4.58, P < 0.001). Total variance in PBVC decreased significantly by a factor of 1.8 after manual editing (sigma(2) = 2.82 before, and sigma(2) = 1.54 after manual editing, P < 0.05). CONCLUSION: Substantial intercenter agreement was found for manually-edited SIENAX and SIENA, suggesting that measurements from multiple centers may be pooled. Manual editing reduces overestimation of NBV, and is likely to increase statistical power for PBVC. |
| first_indexed | 2024-03-07T03:09:53Z |
| format | Journal article |
| id | oxford-uuid:b3d2cff1-304d-44f5-b6c1-d20c4fd29584 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:09:53Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:b3d2cff1-304d-44f5-b6c1-d20c4fd295842022-03-27T04:21:57ZIntercenter agreement of brain atrophy measurement in multiple sclerosis patients using manually-edited SIENA and SIENAX.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b3d2cff1-304d-44f5-b6c1-d20c4fd29584EnglishSymplectic Elements at Oxford2007Jasperse, BValsasina, PNeacsu, VKnol, DDe Stefano, NEnzinger, CSmith, SRopele, SKorteweg, TGiorgio, AAnderson, VPolman, CFilippi, MMiller, DRovaris, MBarkhof, FVrenken, H PURPOSE: To investigate intercenter agreement of brain volume (change) measurement in multiple sclerosis (MS) using structural image evaluation using normalization of atrophy (SIENA) and the cross-sectional version of SIENA (SIENAX) with additional manual editing to correct for inadequate brain extraction. MATERIALS AND METHODS: Baseline and follow-up T1-weighted MR images of 20 MS patients were dispatched to five centers. Each center performed fully-automated and manually-edited analyses for SIENAX, yielding normalized brain volume (NBV), and SIENA, yielding percentage brain volume change (PBVC). Intercenter agreement was assessed with the concordance correlation coefficient (CCC). RESULTS: Intercenter agreement was perfect for fully automated NBV and PBVC (both CCC = 1.0), and remained substantial upon manual editing (CCC = 0.94 for NBV, CCC = 0.95 for PBVC). Mean NBV values for each center decreased significantly after manual editing (overall mean NBV = 1605.3 cm(3) vs. 1651.1 cm(3) without manual editing; t = -4.58, P < 0.001). Total variance in PBVC decreased significantly by a factor of 1.8 after manual editing (sigma(2) = 2.82 before, and sigma(2) = 1.54 after manual editing, P < 0.05). CONCLUSION: Substantial intercenter agreement was found for manually-edited SIENAX and SIENA, suggesting that measurements from multiple centers may be pooled. Manual editing reduces overestimation of NBV, and is likely to increase statistical power for PBVC. |
| spellingShingle | Jasperse, B Valsasina, P Neacsu, V Knol, D De Stefano, N Enzinger, C Smith, S Ropele, S Korteweg, T Giorgio, A Anderson, V Polman, C Filippi, M Miller, D Rovaris, M Barkhof, F Vrenken, H Intercenter agreement of brain atrophy measurement in multiple sclerosis patients using manually-edited SIENA and SIENAX. |
| title | Intercenter agreement of brain atrophy measurement in multiple sclerosis patients using manually-edited SIENA and SIENAX. |
| title_full | Intercenter agreement of brain atrophy measurement in multiple sclerosis patients using manually-edited SIENA and SIENAX. |
| title_fullStr | Intercenter agreement of brain atrophy measurement in multiple sclerosis patients using manually-edited SIENA and SIENAX. |
| title_full_unstemmed | Intercenter agreement of brain atrophy measurement in multiple sclerosis patients using manually-edited SIENA and SIENAX. |
| title_short | Intercenter agreement of brain atrophy measurement in multiple sclerosis patients using manually-edited SIENA and SIENAX. |
| title_sort | intercenter agreement of brain atrophy measurement in multiple sclerosis patients using manually edited siena and sienax |
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