Studies on bone matrix glycoproteins. Incorporation of (1-14C)glucosamine and plasma (14C)glycoprotein into rabbit cortical bone.
The radioactively labelled constituents present in bone matrix were compared 12 days after injection of either [(14)C]glucosamine or plasma [(14)C]glycoprotein. Both precursors are utilized in the synthesis of organic matrix by bone tissue. Cortical bone from animals injected with [(14)C]glucosamine...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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1973
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| _version_ | 1826292136129069056 |
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| author | Triffitt, J Owen, M |
| author_facet | Triffitt, J Owen, M |
| author_sort | Triffitt, J |
| collection | OXFORD |
| description | The radioactively labelled constituents present in bone matrix were compared 12 days after injection of either [(14)C]glucosamine or plasma [(14)C]glycoprotein. Both precursors are utilized in the synthesis of organic matrix by bone tissue. Cortical bone from animals injected with [(14)C]glucosamine contains radioactivity derived from glucosamine and plasma glycoproteins and all glycoprotein fractions are labelled. Plasma [(14)C]glycoprotein labels the less acidic glycoproteins to a greater extent than the more acidic components. An antibody has been raised against the less-acidic-glycoprotein fraction of bone. The latter contains a glycoprotein of alpha-mobility that appears to be concentrated specifically in bone tissue and which is present also in plasma. This alpha-glycoprotein accounts for a large proportion of the components labelled and retained in bone matrix after [(14)C]glucosamine injection. |
| first_indexed | 2024-03-07T03:10:02Z |
| format | Journal article |
| id | oxford-uuid:b3e09b2b-4d56-41a7-a76c-1ebef36a2d01 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:10:02Z |
| publishDate | 1973 |
| record_format | dspace |
| spelling | oxford-uuid:b3e09b2b-4d56-41a7-a76c-1ebef36a2d012022-03-27T04:22:14ZStudies on bone matrix glycoproteins. Incorporation of (1-14C)glucosamine and plasma (14C)glycoprotein into rabbit cortical bone.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b3e09b2b-4d56-41a7-a76c-1ebef36a2d01EnglishSymplectic Elements at Oxford1973Triffitt, JOwen, MThe radioactively labelled constituents present in bone matrix were compared 12 days after injection of either [(14)C]glucosamine or plasma [(14)C]glycoprotein. Both precursors are utilized in the synthesis of organic matrix by bone tissue. Cortical bone from animals injected with [(14)C]glucosamine contains radioactivity derived from glucosamine and plasma glycoproteins and all glycoprotein fractions are labelled. Plasma [(14)C]glycoprotein labels the less acidic glycoproteins to a greater extent than the more acidic components. An antibody has been raised against the less-acidic-glycoprotein fraction of bone. The latter contains a glycoprotein of alpha-mobility that appears to be concentrated specifically in bone tissue and which is present also in plasma. This alpha-glycoprotein accounts for a large proportion of the components labelled and retained in bone matrix after [(14)C]glucosamine injection. |
| spellingShingle | Triffitt, J Owen, M Studies on bone matrix glycoproteins. Incorporation of (1-14C)glucosamine and plasma (14C)glycoprotein into rabbit cortical bone. |
| title | Studies on bone matrix glycoproteins. Incorporation of (1-14C)glucosamine and plasma (14C)glycoprotein into rabbit cortical bone. |
| title_full | Studies on bone matrix glycoproteins. Incorporation of (1-14C)glucosamine and plasma (14C)glycoprotein into rabbit cortical bone. |
| title_fullStr | Studies on bone matrix glycoproteins. Incorporation of (1-14C)glucosamine and plasma (14C)glycoprotein into rabbit cortical bone. |
| title_full_unstemmed | Studies on bone matrix glycoproteins. Incorporation of (1-14C)glucosamine and plasma (14C)glycoprotein into rabbit cortical bone. |
| title_short | Studies on bone matrix glycoproteins. Incorporation of (1-14C)glucosamine and plasma (14C)glycoprotein into rabbit cortical bone. |
| title_sort | studies on bone matrix glycoproteins incorporation of 1 14c glucosamine and plasma 14c glycoprotein into rabbit cortical bone |
| work_keys_str_mv | AT triffittj studiesonbonematrixglycoproteinsincorporationof114cglucosamineandplasma14cglycoproteinintorabbitcorticalbone AT owenm studiesonbonematrixglycoproteinsincorporationof114cglucosamineandplasma14cglycoproteinintorabbitcorticalbone |