| Tóm tắt: | <p><strong>Purpose:</strong><br />
To determine whether low levels of recall lead to increased interval cancers and the magnitude of this effect.</p><br />
<p><strong>Materials and Methods:</strong><br />
The authors retrospectively analyzed prospectively collected data from the UK National Health Service Breast Screening Programme during a 36-month period (April 1, 2005 to March 31, 2008), with 3-year follow-up in women aged 50–70 years. Data on recall, cancers detected at screening, and interval cancers were available for each of the 84 breast screening units and for each year (n = 252). The association between interval cancers and recalls was modeled by using Poisson regression on aggregated data and according to age (5-year intervals) and screening type (prevalent vs incident).</p><br />
<p><strong>Results:</strong><br />
The authors analyzed 5 126 689 screening episodes, demonstrating an average recall to assessment rate (RAR) of 4.56% (range, 1.64%–8.42%; standard deviation, 1.15%), cancer detection rate of 8.1 per 1000 women screened, and interval cancer rate (ICR) of 3.1 per 1000 women screened. Overall, a significant negative association was found between RAR and ICR (Poisson regression coefficient: −0.039 [95% confidence interval: −0.062, −0.017]; P = .001), with approximately one fewer interval cancer for every additional 80–84 recalls. Subgroup analysis revealed similar negative correlations in women aged 50–54 years (P = .002), 60–64 years (P = .01), and 65–69 years (P = .008) as well as in incident screens (P = .001) and prevalent screens (P = .04). No significant relationship was found in women aged 55–59 years (P = .46).</p><br />
<p><strong>Conclusion:</strong><br />
There was a statistically significant negative correlation between RAR and ICR, which suggests the merit of a minimum threshold for RAR.</p>
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