IFN-gamma exposes a cryptic cytotoxic T lymphocyte epitope in HIV-1 reverse transcriptase.
The proteasome, an essential component of the ATP-dependent proteolytic pathway in eukaryotic cells, is responsible for the degradation of most cellular proteins and is believed to be the main source of MHC class I-restricted antigenic peptides for presentation to CTL. Inhibition of the proteasome b...
Hlavní autoři: | Sewell, A, Price, D, Teisserenc, H, Booth, B, Gileadi, U, Flavin, F, Trowsdale, J, Phillips, R, Cerundolo, V |
---|---|
Médium: | Journal article |
Jazyk: | English |
Vydáno: |
1999
|
Podobné jednotky
-
Role of the proteasome and non proteasomal proteases in the generation of CTL epitopes.
Autor: Cerundolo, V, a další
Vydáno: (1998) -
Differential processing of HLA A2-restricted HIV type 1 cytotoxic T lymphocyte epitopes.
Autor: Sewell, A, a další
Vydáno: (2002) -
Generation of an immunodominant CTL epitope is affected by proteasome subunit composition and stability of the antigenic protein.
Autor: Gileadi, U, a další
Vydáno: (1999) -
Effect of epitope flanking residues on the presentation of N-terminal cytotoxic T lymphocyte epitopes.
Autor: Gileadi, U, a další
Vydáno: (1999) -
Effects of retroviral protease inhibitors on proteasome function and processing of HIV-derived MHC class I-restricted cytotoxic T lymphocyte epitopes.
Autor: Kelleher, A, a další
Vydáno: (2001)