Clinical predictors of familial depression in Han Chinese women.
BACKGROUND: A number of clinical features potentially reflect an individual's familial vulnerability to major depression (MD), including early age at onset, recurrence, impairment, episode duration, and the number and pattern of depressive symptoms. However, these results are drawn from studies...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2012
|
| _version_ | 1826292220105326592 |
|---|---|
| author | Wang, L Qiao, D Li, Y Wang, L Ren, J He, K Sun, J Wang, Z Tian, T Chen, C Yang, L Hu, J Deng, H Wang, Q Li, K Han, J Rong, H Gan, Z Yang, H Zhou, P Pan, J Zhou, C Cui, Y Song, L Zhu, Y |
| author_facet | Wang, L Qiao, D Li, Y Wang, L Ren, J He, K Sun, J Wang, Z Tian, T Chen, C Yang, L Hu, J Deng, H Wang, Q Li, K Han, J Rong, H Gan, Z Yang, H Zhou, P Pan, J Zhou, C Cui, Y Song, L Zhu, Y |
| author_sort | Wang, L |
| collection | OXFORD |
| description | BACKGROUND: A number of clinical features potentially reflect an individual's familial vulnerability to major depression (MD), including early age at onset, recurrence, impairment, episode duration, and the number and pattern of depressive symptoms. However, these results are drawn from studies that have exclusively examined individuals from a European ethnic background. We investigated which clinical features of depressive illness index familial vulnerability in Han Chinese females with MD. METHODS: We used lifetime MD and associated clinical features assessed at personal interview in 1,970 Han Chinese women with DSM-IV MD between 30-60 years of age. Odds Ratios were calculated by logistic regression. RESULTS: Individuals with a high familial risk for MD are characterized by severe episodes of MD without known precipitants (such as stress life events) and are less likely to feel irritable/angry or anxious/nervous. CONCLUSIONS: The association between family history of MD and the lack of a precipitating stressor, traditionally a characteristic of endogenous or biological depression, may reflect the association seen in other samples between recurrent MD and a positive family history. The symptomatic associations we have seen may reflect a familial predisposition to other dimensions of psychopathology, such as externalizing disorders or anxiety states. |
| first_indexed | 2024-03-07T03:11:19Z |
| format | Journal article |
| id | oxford-uuid:b44ecdc2-451a-4f9f-a18b-ec37744a79f8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:11:19Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:b44ecdc2-451a-4f9f-a18b-ec37744a79f82022-03-27T04:25:06ZClinical predictors of familial depression in Han Chinese women.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b44ecdc2-451a-4f9f-a18b-ec37744a79f8EnglishSymplectic Elements at Oxford2012Wang, LQiao, DLi, YWang, LRen, JHe, KSun, JWang, ZTian, TChen, CYang, LHu, JDeng, HWang, QLi, KHan, JRong, HGan, ZYang, HZhou, PPan, JZhou, CCui, YSong, LZhu, YBACKGROUND: A number of clinical features potentially reflect an individual's familial vulnerability to major depression (MD), including early age at onset, recurrence, impairment, episode duration, and the number and pattern of depressive symptoms. However, these results are drawn from studies that have exclusively examined individuals from a European ethnic background. We investigated which clinical features of depressive illness index familial vulnerability in Han Chinese females with MD. METHODS: We used lifetime MD and associated clinical features assessed at personal interview in 1,970 Han Chinese women with DSM-IV MD between 30-60 years of age. Odds Ratios were calculated by logistic regression. RESULTS: Individuals with a high familial risk for MD are characterized by severe episodes of MD without known precipitants (such as stress life events) and are less likely to feel irritable/angry or anxious/nervous. CONCLUSIONS: The association between family history of MD and the lack of a precipitating stressor, traditionally a characteristic of endogenous or biological depression, may reflect the association seen in other samples between recurrent MD and a positive family history. The symptomatic associations we have seen may reflect a familial predisposition to other dimensions of psychopathology, such as externalizing disorders or anxiety states. |
| spellingShingle | Wang, L Qiao, D Li, Y Wang, L Ren, J He, K Sun, J Wang, Z Tian, T Chen, C Yang, L Hu, J Deng, H Wang, Q Li, K Han, J Rong, H Gan, Z Yang, H Zhou, P Pan, J Zhou, C Cui, Y Song, L Zhu, Y Clinical predictors of familial depression in Han Chinese women. |
| title | Clinical predictors of familial depression in Han Chinese women. |
| title_full | Clinical predictors of familial depression in Han Chinese women. |
| title_fullStr | Clinical predictors of familial depression in Han Chinese women. |
| title_full_unstemmed | Clinical predictors of familial depression in Han Chinese women. |
| title_short | Clinical predictors of familial depression in Han Chinese women. |
| title_sort | clinical predictors of familial depression in han chinese women |
| work_keys_str_mv | AT wangl clinicalpredictorsoffamilialdepressioninhanchinesewomen AT qiaod clinicalpredictorsoffamilialdepressioninhanchinesewomen AT liy clinicalpredictorsoffamilialdepressioninhanchinesewomen AT wangl clinicalpredictorsoffamilialdepressioninhanchinesewomen AT renj clinicalpredictorsoffamilialdepressioninhanchinesewomen AT hek clinicalpredictorsoffamilialdepressioninhanchinesewomen AT sunj clinicalpredictorsoffamilialdepressioninhanchinesewomen AT wangz clinicalpredictorsoffamilialdepressioninhanchinesewomen AT tiant clinicalpredictorsoffamilialdepressioninhanchinesewomen AT chenc clinicalpredictorsoffamilialdepressioninhanchinesewomen AT yangl clinicalpredictorsoffamilialdepressioninhanchinesewomen AT huj clinicalpredictorsoffamilialdepressioninhanchinesewomen AT dengh clinicalpredictorsoffamilialdepressioninhanchinesewomen AT wangq clinicalpredictorsoffamilialdepressioninhanchinesewomen AT lik clinicalpredictorsoffamilialdepressioninhanchinesewomen AT hanj clinicalpredictorsoffamilialdepressioninhanchinesewomen AT rongh clinicalpredictorsoffamilialdepressioninhanchinesewomen AT ganz clinicalpredictorsoffamilialdepressioninhanchinesewomen AT yangh clinicalpredictorsoffamilialdepressioninhanchinesewomen AT zhoup clinicalpredictorsoffamilialdepressioninhanchinesewomen AT panj clinicalpredictorsoffamilialdepressioninhanchinesewomen AT zhouc clinicalpredictorsoffamilialdepressioninhanchinesewomen AT cuiy clinicalpredictorsoffamilialdepressioninhanchinesewomen AT songl clinicalpredictorsoffamilialdepressioninhanchinesewomen AT zhuy clinicalpredictorsoffamilialdepressioninhanchinesewomen |