Outcome of invasive pneumococcal disease: a UK based study

Methods - The records of 106 children aged less than 5 years with invasive disease caused by Streptococcus pneumoniae were reviewed. Results - The clinical manifestations were meningitis (37%), upper respiratory tract infection (24%), pneumonia (19%), and occult bacteraemia (18%). One child died and...

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Bibliographic Details
Main Authors: Shackley, F, Knox, K, Morris, J, Crook, D, Griffiths, D, Mayon-White, R, George, R, Willocks, L, Moxon, E, Gr, O
Format: Journal article
Language:English
Published: 2000
Description
Summary:Methods - The records of 106 children aged less than 5 years with invasive disease caused by Streptococcus pneumoniae were reviewed. Results - The clinical manifestations were meningitis (37%), upper respiratory tract infection (24%), pneumonia (19%), and occult bacteraemia (18%). One child died and seven had persisting neurological impairment. Five serotypes caused 83% of disease and 92% of the serotypes are included in the seven valent conjugate vaccines which are undergoing trials. Conclusions - These data suggest that S pneumoniae infection is associated with a low case fatality rate but substantial morbidity in the UK.