Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signaling.

TLR signal via Toll-IL-1R (TIR) homology domain-containing adaptor proteins. One of these adaptors, Toll-IL-1R domain-containing adaptor inducing IFN-beta-related adaptor molecule (TRAM), has been shown to be essential for TLR4 signaling in TRAM(-/-) mice and cell lines. Previously, we showed that M...

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Príomhchruthaitheoirí: Sacre, S, Lundberg, A, Andreakos, E, Taylor, C, Feldmann, M, Foxwell, B
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 2007