Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor.
Substrate specificity: Biochemical and crystallographic analyses reveal the hypoxia-inducible factor hydroxylase (FIH) as being promiscuous with respect to the residues that it can hydroxylate in β-position, which in addition to Asn, Asp, and His include Leu and Ser residues. The Ser substrate is ox...
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Bibliographic Details
| Main Authors: |
Yang, M,
Hardy, A,
Chowdhury, R,
Loik, N,
Scotti, J,
McCullagh, J,
Claridge, T,
McDonough, M,
Ge, W,
Schofield, C |
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| Format: | Journal article
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| Language: | English |
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| Published: |
2013
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