Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis.

Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis.

The BDNF receptor, TrkB, is critical to limbic epileptogenesis, but the responsible downstream signaling pathways are unknown. We hypothesized that TrkB-dependent activation of phospholipase Cgamma1 (PLCgamma1) signaling is the key pathway and tested this in trkB(PLC/PLC) mice carrying a mutation (Y...

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Bibliographic Details
Main Authors:	He, X, Pan, E, Sciarretta, C, Minichiello, L, McNamara, J
Format:	Journal article
Language:	English
Published:	2010

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