Structural insights into the broad-spectrum antiviral target endoplasmic reticulum alpha-glucosidase II

Structural insights into the broad-spectrum antiviral target endoplasmic reticulum alpha-glucosidase II

Targeting the host-cell endoplasmic reticulum quality control (ERQC) pathway is an effective broad-spectrum antiviral strategy. The two ER resident α-glucosidases whose sequential action permits entry in this pathway are the targets of glucomimetic inhibitors. Knowledge of the molecular details of t...

Podrobná bibliografie
Hlavní autoři:	Zitzmann, N, Caputo, AT, Alonzi, DS, Kiappes, JL, Struwe, WB, Cross, A, Basu, S, Darlot, B, Roversi, P
Další autoři:	Hilgenfeld, R
Médium:	Book section
Jazyk:	English
Vydáno:	Springer 2018

Podobné jednotky

Structural studies of Endoplasmic Reticulum Glucosidase II
Autor: Caputo, A, a další
Vydáno: (2015)

Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals
Autor: Caputo, A, a další
Vydáno: (2016)

ToP-DNJ, a selective inhibitor of endoplasmic reticulum α-glucosidase II exhibiting anti-flaviviral activity
Autor: Kiappes, JL, a další
Vydáno: (2017)

Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4
Autor: Warfield, KL, a další
Vydáno: (2016)

N-substituted valiolamine derivatives as potent inhibitors of endoplasmic reticulum α-glucosidases I and II with antiviral activity
Autor: Karade, S, a další
Vydáno: (2021)

Structual and biochemical characterisation of the endoplasmic reticulum alpha-glucosidases
Autor: Caputo, A
Vydáno: (2015)

Investigating the inhibition of endoplasmic reticulum α-Glucosidase II for the development of broad-spectrum antivirals
Autor: Bremner, FR
Vydáno: (2023)

Glucosylated free oligosaccharides are biomarkers of endoplasmic- reticulum alpha-glucosidase inhibition.
Autor: Alonzi, D, a další
Vydáno: (2008)

Inhibitors of endoplasmic reticulum alpha-glucosidases potently suppress hepatitis C virus virion assembly and release.
Autor: Qu, X, a další
Vydáno: (2011)

Assessment of repurposed compounds against coronaviruses highlights the antiviral broad-spectrum activity of host-targeting iminosugars and confirms the activity of potent directly acting antivirals
Autor: Brun, J, a další
Vydáno: (2025)

Iminosugars inhibit dengue virus production via inhibition of ER alpha-glucosidases – not glycolipid processing enzymes
Autor: Sayce, AC, a další
Vydáno: (2016)

Targeting ER α-glucosidase I with a single-dose iminosugar treatment protects against lethal influenza and dengue virus infections
Autor: Warfield, K, a další
Vydáno: (2020)

Alpha-glucosidase inhibitors as potential broad based anti-viral agents
Autor: Mehta, A, a další
Vydáno: (1998)

Targeting the host ER alpha glucosidases I and II as antiviral therapy
Autor: Branza-Nichita, N, a další
Vydáno: (2007)

Endoplasmic reticulum targeting liposomes
Autor: Pollock, S, a další
Vydáno: (2011)

Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases--Not Glycolipid Processing Enzymes.
Autor: Andrew C Sayce, a další
Vydáno: (2016-03-01)

Antiviral effects of deoxynojirimycin (DNJ)-based iminosugars in dengue virus-infected primary dendritic cells
Autor: Perera, N, a další
Vydáno: (2022)

Uptake and trafficking of liposomes to the endoplasmic reticulum
Autor: Pollock, S, a další
Vydáno: (2010)

Antiviral mechanisms of small molecules targeting the endoplasmic reticulum and Golgi apparatus
Autor: Howe, JD
Vydáno: (2014)

Antiviral effect of alpha-glucosidase inhibitors on viral morphogenesis and binding properties of hepatitis C virus-like particles.
Autor: Chapel, C, a další
Vydáno: (2006)

Demonstration that endoplasmic reticulum-associated degradation of glycoproteins can occur downstream of processing by endomannosidase.
Autor: Kukushkin, N, a další
Vydáno: (2011)

Iminosugars With Endoplasmic Reticulum α-Glucosidase Inhibitor Activity Inhibit ZIKV Replication and Reverse Cytopathogenicity in vitro
Autor: Gitanjali Bhushan, a další
Vydáno: (2020-04-01)

Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum
Autor: Fabiana Miraglia, a další
Vydáno: (2020-08-01)

Endoplasmic reticulum stress triggers unfolded protein response as an antiviral strategy of teleost erythrocytes
Autor: Maria Salvador-Mira, a další
Vydáno: (2024-11-01)

Iminosugar antivirals: the therapeutic sweet spot
Autor: Alonzi, D, a další
Vydáno: (2017)

Improved cellular inhibitors for glycoprotein processing alpha-glucosidases: biological characterisation of alkyl- and arylalkyl-N-substituted deoxynojirimycins
Autor: Alonzi, D, a další
Vydáno: (2009)

Endoplasmic reticulum associated degradation preserves neurons viability by maintaining endoplasmic reticulum homeostasis
Autor: Shuangchan Wu, a další
Vydáno: (2024-07-01)

The Endoplasmic Reticulum ATP13A1 is Essential for MAVS‐Mediated Antiviral Innate Immunity
Autor: Rui Zhang, a další
Vydáno: (2022-11-01)

Broad-Spectrum Antivirals and Antiviral Drug Combinations
Autor: Valentyn Oksenych, a další
Vydáno: (2022-02-01)

Ceramide synthesis in the endoplasmic reticulum can permeabilize mitochondria to proapoptotic proteins
Autor: Johnny Stiban, a další
Vydáno: (2008-03-01)

Endoplasmic reticulum stress in diseases
Autor: Yingying Liu, a další
Vydáno: (2024-09-01)

Endoplasmic reticulum storage diseases
Autor: M Spiess
Vydáno: (2002-05-01)

Endoplasmic reticulum stress and organoids
Autor: Rashedul Alam, a další
Vydáno: (2021-01-01)

Broad-Spectrum Antiviral Therapeutics
Autor: Rider, Todd H., a další
Vydáno: (2011)

Broad-spectrum antiviral therapeutics.
Autor: Todd H Rider, a další
Vydáno: (2011-01-01)

Broad-spectrum antiviral agents
Autor: Jun-Da eZhu, a další
Vydáno: (2015-05-01)

Broad-Spectrum Antivirals and Antiviral Combinations: An Editorial Update
Autor: Denis Kainov, a další
Vydáno: (2022-10-01)

Synthesis and biological characterisation of novel N-alkyl-deoxynojirimycin alpha-glucosidase inhibitors.
Autor: Rawlings, A, a další
Vydáno: (2009)

The endoplasmic reticulum stress of placental impoverishment.
Autor: Redman, C
Vydáno: (2008)

Endoplasmic Reticulum Stress and Lipid Metabolism
Autor: Huiping Zhou, a další
Vydáno: (2012-01-01)