Structural insights into the broad-spectrum antiviral target endoplasmic reticulum alpha-glucosidase II

Structural insights into the broad-spectrum antiviral target endoplasmic reticulum alpha-glucosidase II

Targeting the host-cell endoplasmic reticulum quality control (ERQC) pathway is an effective broad-spectrum antiviral strategy. The two ER resident α-glucosidases whose sequential action permits entry in this pathway are the targets of glucomimetic inhibitors. Knowledge of the molecular details of t...

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Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Zitzmann, N, Caputo, AT, Alonzi, DS, Kiappes, JL, Struwe, WB, Cross, A, Basu, S, Darlot, B, Roversi, P
Rannpháirtithe:	Hilgenfeld, R
Formáid:	Book section
Teanga:	English
Foilsithe / Cruthaithe:	Springer 2018

Míreanna comhchosúla

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Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals
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Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4
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Glucosylated free oligosaccharides are biomarkers of endoplasmic- reticulum alpha-glucosidase inhibition.
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Assessment of repurposed compounds against coronaviruses highlights the antiviral broad-spectrum activity of host-targeting iminosugars and confirms the activity of potent directly acting antivirals
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Inhibitors of endoplasmic reticulum alpha-glucosidases potently suppress hepatitis C virus virion assembly and release.
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Endoplasmic reticulum targeting liposomes
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Endoplasmic reticulum stress response in yeast and humans
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Cleaning up in the endoplasmic reticulum: ubiquitin in charge.
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Roles of the actin cytoskeleton in structuring the cortical endoplasmic reticulum.
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Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum
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Gut bacterial metabolites modulate endoplasmic reticulum stress
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Antiviral effects of deoxynojirimycin (DNJ)-based iminosugars in dengue virus-infected primary dendritic cells
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