Synthesis of alkyne- and azide-modified oligonucleotides and their cyclization by the CuAAC (click) reaction.
The Cu(I)-catalyzed alkyne-azide cycloaddition (CuAAC) reaction has been used to synthesize cyclic mini-DNA duplexes. The reaction is carried out on 5'-alkyne-3'-azide-labeled hairpin loop oligonucleotides and proceeds in high yield under mild conditions in as little as 5 min. The resultan...
| Հիմնական հեղինակներ: | , |
|---|---|
| Ձևաչափ: | Journal article |
| Լեզու: | English |
| Հրապարակվել է: |
2008
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Synthesis of alkyne- and azide-modified oligonucleotides and their cyclization by the CuAAC (click) reaction.
Հրապարակվել է 2008
Journal article