Synthesis of alkyne- and azide-modified oligonucleotides and their cyclization by the CuAAC (click) reaction.
The Cu(I)-catalyzed alkyne-azide cycloaddition (CuAAC) reaction has been used to synthesize cyclic mini-DNA duplexes. The reaction is carried out on 5'-alkyne-3'-azide-labeled hairpin loop oligonucleotides and proceeds in high yield under mild conditions in as little as 5 min. The resultan...
| Main Authors: | , |
|---|---|
| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2008
|
Search Result 1
Synthesis of alkyne- and azide-modified oligonucleotides and their cyclization by the CuAAC (click) reaction.
Izdano 2008
Journal article