Sarcolemmal nNOS anchoring reveals a qualitative difference between dystrophin and utrophin

Duchenne muscular dystrophy (DMD) is a lethal muscle disease caused by dystrophin deficiency. In normal muscle, dystrophin helps maintain sarcolemmal stability. Dystrophin also recruits neuronal nitric oxide synthase (nNOS) to the sarcolemma. Failure to anchor nNOS to the membrane leads to functiona...

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Bibliografske podrobnosti
Main Authors: Li, D, Bareja, A, Judge, L, Yue, Y, Lai, Y, Fairclough, R, Davies, K, Chamberlain, J, Duan, D
Format: Journal article
Jezik:English
Izdano: 2010