Monoclonal antibodies targeting the disintegrin-like domain of ADAMDEC1 modulates the proteolytic activity and enables quantification of ADAMDEC1 protein in human plasma

Monoclonal antibodies targeting the disintegrin-like domain of ADAMDEC1 modulates the proteolytic activity and enables quantification of ADAMDEC1 protein in human plasma

Decysin-1 (ADAMDEC1) is an orphan ADAM-like metalloprotease with unknown biological function and a short domain structure. ADAMDEC1 mRNA has previously been demonstrated primarily in macrophages and mature dendritic cells. Here, we generated monoclonal antibodies (mAbs) against the mature ADAMDEC1 p...

Descrizione completa

Dettagli Bibliografici
Autori principali:	Lund, J, Elimar Bitsch, A, Grønbech Rasch, M, Enoksson, M, Troeberg, L, Nagase, H, Loftager, M, Overgaard, M, Petersen, H
Natura:	Journal article
Lingua:	English
Pubblicazione:	Taylor and Francis 2017

Documenti analoghi

Evidence for Restricted Reactivity of ADAMDEC1 with Protein Substrates and Endogenous Inhibitors.
di: Lund, J, et al.
Pubblicazione: (2015)

ADAMDEC1 accelerates GBM progression via activation of the MMP2-related pathway
di: Huimin Qi, et al.
Pubblicazione: (2022-09-01)

ADAMDEC1 promotes the malignant progression of cholangiocarcinoma by regulating NF-κB signaling pathway
di: Shuo Zhou, et al.
Pubblicazione: (2025-01-01)

ADAMDEC1 and FGF2/FGFR1 signaling constitute a positive feedback loop to maintain GBM cancer stem cells
di: Ana Jimenez-Pascual, et al.
Pubblicazione: (2020-01-01)

Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding.
di: Yamamoto, K, et al.
Pubblicazione: (2014)

Disintegrins from Hematophagous Sources
di: Ivo M. B. Francischetti, et al.
Pubblicazione: (2012-04-01)

Snake Venom Disintegrins and Cell Migration
di: Heloisa S. Selistre-de-Araujo, et al.
Pubblicazione: (2010-10-01)

Proteolytic fragments of tenascin-C promote cartilage degradation
di: Sofat, N, et al.
Pubblicazione: (2010)

Trypanosoma cruzy proteolytic activities after immunoprecipitation with the monoclonal antibody H1A10
di: Eloise Cedro Fernandes
Pubblicazione: (2018-01-01)

Aggrecan breakdown in cartilage induced by proteolytic fragments of fibronectin: implications in osteoarthritis
di: Nagase, H
Pubblicazione: (2009)

The Role of Snake Venom Disintegrins in Angiogenesis
di: Patricia Bianca Clissa, et al.
Pubblicazione: (2024-03-01)

Recombinant and Chimeric Disintegrins in Preclinical Research
di: Victor David, et al.
Pubblicazione: (2018-08-01)

Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases
di: D. Dreymueller, et al.
Pubblicazione: (2017-01-01)

Voltage-Gated Calcium Channel alpha(2)delta Subunits in Lipid Rafts: The Importance of Proteolytic Cleavage Into alpha(2) and delta
di: Kadurin, I, et al.
Pubblicazione: (2012)

Detectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 in serum is associated with adverse outcome in pediatric sepsis
di: Boeddha, NP, et al.
Pubblicazione: (2021)

Proteolytic cleavage of antigen extends the durability of an anti-PCSK9 monoclonal antibody[S]
di: Krista M. Schroeder, et al.
Pubblicazione: (2015-11-01)

Detectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis
di: Navin P. Boeddha, MD, PhD, et al.
Pubblicazione: (2021-11-01)

Monoclonal Antibodies that Inhibit the Proteolytic Activity of Botulinum Neurotoxin Serotype/B
di: Yongfeng Fan, et al.
Pubblicazione: (2015-08-01)

Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate.
di: Lauer-Fields, J, et al.
Pubblicazione: (2008)

A Disintegrin and Metalloprotease 33 polymorphisms and lung function decline in the general population
di: Cleo. C. van Diemen, et al.
Pubblicazione: (2006-12-01)

Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity
di: Gossens, K, et al.
Pubblicazione: (2010)

Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity.
di: Gossens, K, et al.
Pubblicazione: (2010)

A DISINTEGRIN AND METALLOPROTEASE 17 IN THE CARDIOVASCULAR AND CENTRAL NERVOUS SYSTEMS
di: Jiaxi Xu, et al.
Pubblicazione: (2016-10-01)

A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their Functions
di: Nives Giebeler, et al.
Pubblicazione: (2016-04-01)

ADAM-15 Disintegrin-Like Domain Structure and Function
di: Dong Lu, et al.
Pubblicazione: (2010-10-01)

A Disintegrin and Metalloproteinase—Control Elements in Infectious Diseases
di: Ahmad Aljohmani, et al.
Pubblicazione: (2020-12-01)

MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms
di: Gifford, V, et al.
Pubblicazione: (2019)

Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration
di: Gregor Bieri, et al.
Pubblicazione: (2018-12-01)

THE TYPE III 8-10 REPEATS OF FIBRONECTIN INDUCE AGGRECANASE ACTIVITY VIA ALPHA5BETA1 INTEGRIN AND THE TYPE III 13-14 REPEATS ACT VIA TLR 4 RECEPTORS
di: Sofat, N, et al.
Pubblicazione: (2009)

The type III 8-10 repeats of fibronectin induce aggrecanase activity via alpha(5)beta(1) integrin and type III 13-14 repeats act via TLR 4 receptors
di: Sofat, N, et al.
Pubblicazione: (2009)

Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing.
di: Kashiwagi, M, et al.
Pubblicazione: (2004)

ADAM15 Disintegrin Is Associated with Aggressive Prostate and Breast Cancer Disease
di: Rainer Kuefer, et al.
Pubblicazione: (2006-04-01)

Snake venom disintegrins update: insights about new findings
di: Gabriela de Oliveira Almeida, et al.
Pubblicazione: (2023-09-01)

Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
di: Gendron, C, et al.
Pubblicazione: (2007)

Alternagin-C, a disintegrin-like protein from the venom of Bothrops alternatus, modulates a2ß1 integrin-mediated cell adhesion, migration and proliferation
di: Selistre-de-Araujo H.S., et al.
Pubblicazione: (2005-01-01)

Monitoring metalloproteinase activity using synthetic fluorogenic substrates.
di: Troeberg, L, et al.
Pubblicazione: (2004)

Calcium pentosan polysulfate is a multi-functional aggrecanase inhibitor that enhances interaction with endogenous TIMP-3 in cartilage
di: Troeberg, L, et al.
Pubblicazione: (2009)

Proteases involved in cartilage matrix degradation in osteoarthritis.
di: Troeberg, L, et al.
Pubblicazione: (2012)

Measurement of matrix metalloproteinase activities in the medium of cultured synoviocytes using zymography.
di: Troeberg, L, et al.
Pubblicazione: (2003)

Zymography of metalloproteinases.
di: Troeberg, L, et al.
Pubblicazione: (2004)