A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG mediated protection in a murine model of tuberculosis

A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG mediated protection in a murine model of tuberculosis

<h4>Background</h4> <p>In the absence of a validated animal model and/or an immune correlate which predict vaccine-mediated protection, large-scale clinical trials are currently the only option to prove efficacy of new tuberculosis candidate vaccines. Tools to facilitate testing of...

Bibliografski detalji
Glavni autori:	McShane, H, Tanner, R, Zelmer, A, Stylianou, E, Damelang, T, Morris, S, Izzo, A, Williams, A, Sharpe, S, Pepponi, I, Walker, B, Hokey, D, Brennan, M, Fletcher, H
Format:	Journal article
Izdano:	BioMed Central 2016

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od: Prabowo, SA, i dr.
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od: Poyntz, H, i dr.
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Izdano: (2013)

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od: Sander, C, i dr.
Izdano: (2006)

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od: Mcshane, H, i dr.
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od: Poyntz, H, i dr.
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