Gender effect on neuromyelitis optica spectrum disorder with aquaporin4-immunoglobulin G
<h4>Background</h4> <p>Neuromyelitis optica spectrum disorder with aquaporin4-immunoglobulin G (NMOSD-AQP4) is an inflammatory demyelinating disease characterised by a high female predominance. However, the effect of gender in patients with NMOSD-AQP4 has not been fully evaluated,...
| Main Authors: | , , , , , , , , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
SAGE Publications
2016
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| _version_ | 1826292316422275072 |
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| author | Kim, S-M Waters, P Woodhall, M Kim, Y-J Kim, J-A Cheon, SY Lee, S Jo, SR Kim, DG Jung, KC Lee, K-W Sung, J-J Park, KS |
| author_facet | Kim, S-M Waters, P Woodhall, M Kim, Y-J Kim, J-A Cheon, SY Lee, S Jo, SR Kim, DG Jung, KC Lee, K-W Sung, J-J Park, KS |
| author_sort | Kim, S-M |
| collection | OXFORD |
| description | <h4>Background</h4> <p>Neuromyelitis optica spectrum disorder with aquaporin4-immunoglobulin G (NMOSD-AQP4) is an inflammatory demyelinating disease characterised by a high female predominance. However, the effect of gender in patients with NMOSD-AQP4 has not been fully evaluated, particularly in Asian populations.</p> <h4>Objective</h4> <p>To determine the effect of gender in clinical manifestations and prognosis of patients with NMOSD-AQP4 among Asians.</p> <h4>Methods</h4> <p>The demographics, clinical and radiological characteristics, pattern reversal visual evoked potential (VEP) test results, and prognosis of 106 patients (18 male) with NMOSD-AQP4 were assessed.</p> <h4>Results</h4> <p>Male patients had a higher age at onset (48.7 years vs 41 years, p =0.037), higher tendency to manifest as isolated myelitis (67% vs. 28%, p = 0.005), fewer optic neuritis attacks per year (0.08 vs. 0.27, p < 0.001), and shorter relative P100 latency on VEP testing (97.1% vs 108.3%, p = 0.001). Moreover, male gender was significantly associated with the absence of optic neuritis attacks independent of their age of onset. </p> <h4>Conclusion</h4> <p>In Asian NMOSD-AQP4 patients gender impacts on disease onset age and site of attack. This may be an important diagnostic clue in NMOSD-AQP4 patients with limited manifestations and suggests a better visual prognosis.</p> |
| first_indexed | 2024-03-07T03:12:48Z |
| format | Journal article |
| id | oxford-uuid:b4c70dbc-1a57-499c-a208-dcc02faf33d0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:12:48Z |
| publishDate | 2016 |
| publisher | SAGE Publications |
| record_format | dspace |
| spelling | oxford-uuid:b4c70dbc-1a57-499c-a208-dcc02faf33d02022-03-27T04:28:43ZGender effect on neuromyelitis optica spectrum disorder with aquaporin4-immunoglobulin GJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b4c70dbc-1a57-499c-a208-dcc02faf33d0EnglishSymplectic Elements at OxfordSAGE Publications2016Kim, S-MWaters, PWoodhall, MKim, Y-JKim, J-ACheon, SYLee, SJo, SRKim, DGJung, KCLee, K-WSung, J-JPark, KS <h4>Background</h4> <p>Neuromyelitis optica spectrum disorder with aquaporin4-immunoglobulin G (NMOSD-AQP4) is an inflammatory demyelinating disease characterised by a high female predominance. However, the effect of gender in patients with NMOSD-AQP4 has not been fully evaluated, particularly in Asian populations.</p> <h4>Objective</h4> <p>To determine the effect of gender in clinical manifestations and prognosis of patients with NMOSD-AQP4 among Asians.</p> <h4>Methods</h4> <p>The demographics, clinical and radiological characteristics, pattern reversal visual evoked potential (VEP) test results, and prognosis of 106 patients (18 male) with NMOSD-AQP4 were assessed.</p> <h4>Results</h4> <p>Male patients had a higher age at onset (48.7 years vs 41 years, p =0.037), higher tendency to manifest as isolated myelitis (67% vs. 28%, p = 0.005), fewer optic neuritis attacks per year (0.08 vs. 0.27, p < 0.001), and shorter relative P100 latency on VEP testing (97.1% vs 108.3%, p = 0.001). Moreover, male gender was significantly associated with the absence of optic neuritis attacks independent of their age of onset. </p> <h4>Conclusion</h4> <p>In Asian NMOSD-AQP4 patients gender impacts on disease onset age and site of attack. This may be an important diagnostic clue in NMOSD-AQP4 patients with limited manifestations and suggests a better visual prognosis.</p> |
| spellingShingle | Kim, S-M Waters, P Woodhall, M Kim, Y-J Kim, J-A Cheon, SY Lee, S Jo, SR Kim, DG Jung, KC Lee, K-W Sung, J-J Park, KS Gender effect on neuromyelitis optica spectrum disorder with aquaporin4-immunoglobulin G |
| title | Gender effect on neuromyelitis optica spectrum disorder with aquaporin4-immunoglobulin G |
| title_full | Gender effect on neuromyelitis optica spectrum disorder with aquaporin4-immunoglobulin G |
| title_fullStr | Gender effect on neuromyelitis optica spectrum disorder with aquaporin4-immunoglobulin G |
| title_full_unstemmed | Gender effect on neuromyelitis optica spectrum disorder with aquaporin4-immunoglobulin G |
| title_short | Gender effect on neuromyelitis optica spectrum disorder with aquaporin4-immunoglobulin G |
| title_sort | gender effect on neuromyelitis optica spectrum disorder with aquaporin4 immunoglobulin g |
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