Modulation of interleukin 1 beta gene expression using antisense phosphorothioate oligonucleotides.

Modulation of interleukin 1 beta gene expression using antisense phosphorothioate oligonucleotides.

The production of interleukin 1 beta (IL1 beta) in lipopolysaccharide (LPS) stimulated monocytes was inhibited by 98% using antisense phosphorothioate oligonucleotides complementary to the 5' untranslated and exon 6 regions of IL1 beta mRNA. A sense phosphorothioate oligonucleotide failed to in...

Podrobná bibliografie
Hlavní autoři:	Manson, J, Brown, T, Duff, G
Médium:	Journal article
Jazyk:	English
Vydáno:	1990

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