An inhibitor of complement C5 provides structural insights into activation
The complement system is a crucial part of innate immune defenses against invading pathogens. The blood-meal of the tick Rhipicephalus pulchellus lasts for days, and the tick must therefore rely on inhibitors to counter complement activation. We have identified a class of inhibitors from tick saliva...
Main Authors: | Reichhardt, M, Johnson, S, Tang, T, Morgan, T, Tebeka, N, Popitsch, N, Deme, J, Jore, M, Lea, S |
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Format: | Journal article |
Sprog: | English |
Udgivet: |
National Academy of Sciences
2019
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Lignende værker
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A novel inhibitor of complement C5 provides structural insights into activation
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Structural basis for therapeutic inhibition of complement C5.
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Structure of and influence of a tick complement inhibitor on human complement component 5.
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Intracellular complement activation—An alarm raising mechanism?
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