An inhibitor of complement C5 provides structural insights into activation

An inhibitor of complement C5 provides structural insights into activation

The complement system is a crucial part of innate immune defenses against invading pathogens. The blood-meal of the tick Rhipicephalus pulchellus lasts for days, and the tick must therefore rely on inhibitors to counter complement activation. We have identified a class of inhibitors from tick saliva...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Reichhardt, M, Johnson, S, Tang, T, Morgan, T, Tebeka, N, Popitsch, N, Deme, J, Jore, M, Lea, S
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	National Academy of Sciences 2019

Những quyển sách tương tự

A novel inhibitor of complement C5 provides structural insights into activation
Bằng: Reichhardt, M, et al.
Được phát hành: (2019)

Structural basis for therapeutic inhibition of complement C5.
Bằng: Jore, M, et al.
Được phát hành: (2016)

Structure of and influence of a tick complement inhibitor on human complement component 5.
Bằng: Fredslund, F, et al.
Được phát hành: (2008)

Erratum: Structure of and influence of a tick complement inhibitor on human complement component 5.
Bằng: Fredslund, F, et al.
Được phát hành: (2008)

Intracellular complement activation—An alarm raising mechanism?
Bằng: Reichhardt, M, et al.
Được phát hành: (2018)

The structure of OMCI, a novel lipocalin inhibitor of the complement system.
Bằng: Roversi, P, et al.
Được phát hành: (2007)

Structure of and influence of a tick complement inhibitor on human complement component 5 (vol 9, pg 753, 2008)
Bằng: Fredslund, F, et al.
Được phát hành: (2008)

Putting the structure into complement.
Bằng: Lea, S, et al.
Được phát hành: (2012)

Structural insights into complement function via studies of pathogen derived proteins
Bằng: Roversi, P, et al.
Được phát hành: (2007)

Molecular Basis for <named-content content-type="genus-species">Bordetella pertussis</named-content> Interference with Complement, Coagulation, Fibrinolytic, and Contact Activation Systems: the Cryo-EM Structure of the Vag8-C1 Inhibitor Complex
Bằng: Arun Dhillon, et al.
Được phát hành: (2021-04-01)

Complement C3 inhibitor in patients with paroxysmal nocturnal hemoglobinuria with suboptimal response to C5 inhibitor therapy
Bằng: M. V. Marchenko, et al.
Được phát hành: (2024-09-01)

Complement inhibitor of C5 activation from the soft tick Ornithodoros moubata.
Bằng: Nunn, M, et al.
Được phát hành: (2005)

Structure of human complement C8, a precursor to membrane attack
Bằng: Bubeck, D, et al.
Được phát hành: (2011)

Structure of human complement C8, a precursor to membrane attack.
Bằng: Bubeck, D, et al.
Được phát hành: (2011)

Structure of human complement C8, a precursor to membrane attack
Bằng: Bubeck, D, et al.
Được phát hành: (2011)

Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase.
Bằng: Nicola N Lynskey, et al.
Được phát hành: (2017-08-01)

Monoclonal Antibodies Capable of Inhibiting Complement Downstream of C5 in Multiple Species
Bằng: Wioleta M. Zelek, et al.
Được phát hành: (2020-12-01)

Structure of the extracellular portion of CD46 provides insights into its interactions with complement proteins and pathogens.
Bằng: B David Persson, et al.
Được phát hành: (2010-09-01)

Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors
Bằng: Christina Lamers, et al.
Được phát hành: (2022-09-01)

Dimerization of complement factor H-related proteins modulates complement activation in vivo.
Bằng: Goicoechea de Jorge, E, et al.
Được phát hành: (2013)

Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR-fold
Bằng: Reichhardt, M, et al.
Được phát hành: (2020)

Inhibition of Immune Complex Complement Activation and Neutrophil Extracellular Trap Formation by Peptide Inhibitor of Complement C1
Bằng: Pamela S. Hair, et al.
Được phát hành: (2018-03-01)

Single-particle electron microscopy reconstruction of the structure of complement component 8 (C8) at 23 angstrom resolution
Bằng: Roversi, P, et al.
Được phát hành: (2008)

Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes.
Bằng: Jialei Xie, et al.
Được phát hành: (2019-03-01)

Structures of the rat complement regulator CrrY
Bằng: Roversi, P, et al.
Được phát hành: (2011)

Structures of the rat complement regulator CrrY.
Bằng: Roversi, P, et al.
Được phát hành: (2011)

Structural findings in complement factor H-related proteins unravel the pathogenesis of C3 glomerulopathy
Bằng: de Jorge, E, et al.
Được phát hành: (2012)

Further structural insights into the binding of complement factor H by complement regulator-acquiring surface protein 1 (CspA) of Borrelia burgdorferi.
Bằng: Caesar, J, et al.
Được phát hành: (2013)

Nanobodies Provide Insight into the Molecular Mechanisms of the Complement Cascade and Offer New Therapeutic Strategies
Bằng: Alessandra Zarantonello, et al.
Được phát hành: (2021-02-01)

Complement Component 5 (C5) Deficiency Improves Cognitive Outcome After Traumatic Brain Injury and Enhances Treatment Effects of Complement Inhibitors C1-Inh and CR2-Crry in a Mouse Model
Bằng: Min Chen, et al.
Được phát hành: (2023-10-01)

Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis
Bằng: Myriam Martin, et al.
Được phát hành: (2023-06-01)

Plasmin as a complement C5 convertase
Bằng: Lawrence L. Leung, et al.
Được phát hành: (2016-03-01)

Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b
Bằng: Ramon M. van den Bos, et al.
Được phát hành: (2019-09-01)

Kinetic analysis of the interaction between the complement regulators CD46 and CD55 and components of the alternative pathway of complement
Bằng: Harris, C, et al.
Được phát hành: (2004)

Structural modelling of human complement FHR1 and two of its synthetic derivatives provides insight into their in-vivo functions
Bằng: Natalia Ruiz-Molina, et al.
Được phát hành: (2023-01-01)

Structural insights into a novel properdin-binding tick inhibitor from Rhipicephalus pulchellus
Bằng: Ahn, J, et al.
Được phát hành: (2018)

Complement Inhibitors in Rare Diseases
Bằng: YUE Cai, et al.
Được phát hành: (2022-10-01)

Structural basis for recognition of the pore-forming toxin intermedilysin by human complement receptor CD59.
Bằng: Johnson, S, et al.
Được phát hành: (2013)

The allosteric modulation of Complement C5 by knob domain peptides
Bằng: Macpherson, A, et al.
Được phát hành: (2021)

Complement C3 and C5 deficiency affects fracture healing.
Bằng: Christian Ehrnthaller, et al.
Được phát hành: (2013-01-01)