Adiposity and blood pressure in 110,000 Mexican adults
Previous studies have reached differing conclusions about the importance of general versus central markers of adiposity to blood pressure, leading to suggestions that population-specific adiposity thresholds may be needed. We examined the relevance of adiposity to blood pressure among 111,911 men an...
| Principais autores: | , , , , , , , , , , |
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| Formato: | Journal article |
| Publicado em: |
American Heart Association
2017
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| _version_ | 1826292345116557312 |
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| author | Gnatiuc, L Alegre-Díaz, J Halsey, J Herrington, W López-Cervantes, M Lewington, S Collins, R Tapia-Conyer, R Peto, R Emberson, J Kuri-Morales, P |
| author_facet | Gnatiuc, L Alegre-Díaz, J Halsey, J Herrington, W López-Cervantes, M Lewington, S Collins, R Tapia-Conyer, R Peto, R Emberson, J Kuri-Morales, P |
| author_sort | Gnatiuc, L |
| collection | OXFORD |
| description | Previous studies have reached differing conclusions about the importance of general versus central markers of adiposity to blood pressure, leading to suggestions that population-specific adiposity thresholds may be needed. We examined the relevance of adiposity to blood pressure among 111,911 men and women who, when recruited into the Mexico City Prospective Study, were aged 35-89, had no chronic disease, and were not taking antihypertensives. Linear regression was used to estimate the effects on systolic (SBP) and diastolic (DBP) blood pressure of two markers of general adiposity (body-mass index [BMI, height-adjusted-weight [HtaW]) and four markers of central adiposity (waist-circumference [WC], hip-circumferences [HC], their ratio [WHR] and waist-height ratio [WHtR]), adjusted for relevant confounders. Mean (SD) adiposity levels were: BMI (28.7±4.5 kg/m2); HtaW (70.2±11.2 kgs); WC (93.3±10.6 cms); HC (104.0±9.0 cms); WHR (0.90±0.06); and WHtR (0.60±0.07). Associations with blood pressure were linear with no threshold levels below which lower general or central adiposity was not associated with lower blood pressure. On average, each 1 standard deviation (SD) higher measured adiposity marker was associated with a 3 mmHg higher SBP and 2 mmHg higher DBP (SEs <0.1 mmHg), but for the WHR, associations were only half as strong. General adiposity associations were independent of central adiposity, but central adiposity associations were substantially reduced by adjustment for general adiposity. Findings were similar for men and women. In Mexican adults, often overweight or obese, markers of general adiposity were stronger predictors of blood pressure than measured markers of central adiposity, with no threshold effects. |
| first_indexed | 2024-03-07T03:13:15Z |
| format | Journal article |
| id | oxford-uuid:b4ed2afa-4809-4103-8600-e276cdf98c6b |
| institution | University of Oxford |
| last_indexed | 2024-03-07T03:13:15Z |
| publishDate | 2017 |
| publisher | American Heart Association |
| record_format | dspace |
| spelling | oxford-uuid:b4ed2afa-4809-4103-8600-e276cdf98c6b2022-03-27T04:29:42ZAdiposity and blood pressure in 110,000 Mexican adultsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b4ed2afa-4809-4103-8600-e276cdf98c6bSymplectic Elements at OxfordAmerican Heart Association2017Gnatiuc, LAlegre-Díaz, JHalsey, JHerrington, WLópez-Cervantes, MLewington, SCollins, RTapia-Conyer, RPeto, REmberson, JKuri-Morales, PPrevious studies have reached differing conclusions about the importance of general versus central markers of adiposity to blood pressure, leading to suggestions that population-specific adiposity thresholds may be needed. We examined the relevance of adiposity to blood pressure among 111,911 men and women who, when recruited into the Mexico City Prospective Study, were aged 35-89, had no chronic disease, and were not taking antihypertensives. Linear regression was used to estimate the effects on systolic (SBP) and diastolic (DBP) blood pressure of two markers of general adiposity (body-mass index [BMI, height-adjusted-weight [HtaW]) and four markers of central adiposity (waist-circumference [WC], hip-circumferences [HC], their ratio [WHR] and waist-height ratio [WHtR]), adjusted for relevant confounders. Mean (SD) adiposity levels were: BMI (28.7±4.5 kg/m2); HtaW (70.2±11.2 kgs); WC (93.3±10.6 cms); HC (104.0±9.0 cms); WHR (0.90±0.06); and WHtR (0.60±0.07). Associations with blood pressure were linear with no threshold levels below which lower general or central adiposity was not associated with lower blood pressure. On average, each 1 standard deviation (SD) higher measured adiposity marker was associated with a 3 mmHg higher SBP and 2 mmHg higher DBP (SEs <0.1 mmHg), but for the WHR, associations were only half as strong. General adiposity associations were independent of central adiposity, but central adiposity associations were substantially reduced by adjustment for general adiposity. Findings were similar for men and women. In Mexican adults, often overweight or obese, markers of general adiposity were stronger predictors of blood pressure than measured markers of central adiposity, with no threshold effects. |
| spellingShingle | Gnatiuc, L Alegre-Díaz, J Halsey, J Herrington, W López-Cervantes, M Lewington, S Collins, R Tapia-Conyer, R Peto, R Emberson, J Kuri-Morales, P Adiposity and blood pressure in 110,000 Mexican adults |
| title | Adiposity and blood pressure in 110,000 Mexican adults |
| title_full | Adiposity and blood pressure in 110,000 Mexican adults |
| title_fullStr | Adiposity and blood pressure in 110,000 Mexican adults |
| title_full_unstemmed | Adiposity and blood pressure in 110,000 Mexican adults |
| title_short | Adiposity and blood pressure in 110,000 Mexican adults |
| title_sort | adiposity and blood pressure in 110 000 mexican adults |
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