Characterizing visual fields in RPGR related retinitis pigmentosa using octopus static-automated perimetry
<p><strong>Purpose:</strong> Peripheral visual fields have not been as well defined by static automated perimetry as kinetic perimetry in <i>RPGR</i>-related retinitis pigmentosa. This study explores the pattern and sensitivities of peripheral visual fields, which may p...
| Auteurs principaux: | , , , , , |
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| Format: | Journal article |
| Langue: | English |
| Publié: |
Association for Research in Vision and Ophthalmology
2022
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| _version_ | 1826310935573168128 |
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| author | Buckley, TMW Josan, AS Taylor, LJ Jolly, JK Cehajic-Kapetanovic, J MacLaren, RE |
| author_facet | Buckley, TMW Josan, AS Taylor, LJ Jolly, JK Cehajic-Kapetanovic, J MacLaren, RE |
| author_sort | Buckley, TMW |
| collection | OXFORD |
| description | <p><strong>Purpose:</strong> Peripheral visual fields have not been as well defined by static automated perimetry as kinetic perimetry in <i>RPGR</i>-related retinitis pigmentosa. This study explores the pattern and sensitivities of peripheral visual fields, which may provide an important end point when assessing interventional clinical trials.</p>
<p><strong>Methods:</strong> A retrospective observational cross-sectional study of 10 genetically confirmed <i>RPGR</i> subjects was performed. Visual fields were obtained using the Octopus 900 perimeter. Interocular symmetry and repeatability were quantified. Visual fields were subdivided into central and peripheral subfields for analysis.</p>
<p><strong>Results:</strong> Mean patient age was 32 years old (20 to 49 years old). Average mean sensitivity was 7 dB (SD = 3.67 dB) and 6.8 dB (SD = 3.4 dB) for the right and left eyes, respectively, demonstrating interocular symmetry. Coefficient of repeatability for overall mean sensitivity: <2 dB. Nine out of 10 subjects had a preserved inferotemporal subfield, whose mean sensitivity was highly correlated to the central field (r<sup>2</sup> = 0.78, <i>P</i> = 0.002 and r<sup>2</sup> = 0.72, <i>P</i> = 0.002 for the right and left eyes, respectively). Within the central field, sensitivities were greater in the temporal than the nasal half (<i>t</i>-test, <i>P</i> = 0.01 and <i>P</i> = 0.03 for the right and left eyes, respectively).</p>
<p><strong>Conclusions:</strong> Octopus static-automated perimeter demonstrates good repeatability. Interocular symmetry permits use of the noninterventional eye as an internal control. In this cohort, the inferotemporal and central visual fields are preserved into later disease stages likely mapping to populations of surviving cones.</p>
<p><strong>Translational Relevance:</strong> A consistently preserved inferotemporal island of vision highly correlated to that of the central visual field may have significance as a possible future therapeutic site.</p> |
| first_indexed | 2024-03-07T08:00:55Z |
| format | Journal article |
| id | oxford-uuid:b4fc1483-a656-4f12-bc76-b4f8b27a71b2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:00:55Z |
| publishDate | 2022 |
| publisher | Association for Research in Vision and Ophthalmology |
| record_format | dspace |
| spelling | oxford-uuid:b4fc1483-a656-4f12-bc76-b4f8b27a71b22023-09-20T13:54:28ZCharacterizing visual fields in RPGR related retinitis pigmentosa using octopus static-automated perimetryJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b4fc1483-a656-4f12-bc76-b4f8b27a71b2EnglishSymplectic ElementsAssociation for Research in Vision and Ophthalmology2022Buckley, TMWJosan, ASTaylor, LJJolly, JKCehajic-Kapetanovic, JMacLaren, RE<p><strong>Purpose:</strong> Peripheral visual fields have not been as well defined by static automated perimetry as kinetic perimetry in <i>RPGR</i>-related retinitis pigmentosa. This study explores the pattern and sensitivities of peripheral visual fields, which may provide an important end point when assessing interventional clinical trials.</p> <p><strong>Methods:</strong> A retrospective observational cross-sectional study of 10 genetically confirmed <i>RPGR</i> subjects was performed. Visual fields were obtained using the Octopus 900 perimeter. Interocular symmetry and repeatability were quantified. Visual fields were subdivided into central and peripheral subfields for analysis.</p> <p><strong>Results:</strong> Mean patient age was 32 years old (20 to 49 years old). Average mean sensitivity was 7 dB (SD = 3.67 dB) and 6.8 dB (SD = 3.4 dB) for the right and left eyes, respectively, demonstrating interocular symmetry. Coefficient of repeatability for overall mean sensitivity: <2 dB. Nine out of 10 subjects had a preserved inferotemporal subfield, whose mean sensitivity was highly correlated to the central field (r<sup>2</sup> = 0.78, <i>P</i> = 0.002 and r<sup>2</sup> = 0.72, <i>P</i> = 0.002 for the right and left eyes, respectively). Within the central field, sensitivities were greater in the temporal than the nasal half (<i>t</i>-test, <i>P</i> = 0.01 and <i>P</i> = 0.03 for the right and left eyes, respectively).</p> <p><strong>Conclusions:</strong> Octopus static-automated perimeter demonstrates good repeatability. Interocular symmetry permits use of the noninterventional eye as an internal control. In this cohort, the inferotemporal and central visual fields are preserved into later disease stages likely mapping to populations of surviving cones.</p> <p><strong>Translational Relevance:</strong> A consistently preserved inferotemporal island of vision highly correlated to that of the central visual field may have significance as a possible future therapeutic site.</p> |
| spellingShingle | Buckley, TMW Josan, AS Taylor, LJ Jolly, JK Cehajic-Kapetanovic, J MacLaren, RE Characterizing visual fields in RPGR related retinitis pigmentosa using octopus static-automated perimetry |
| title | Characterizing visual fields in RPGR related retinitis pigmentosa using octopus static-automated perimetry |
| title_full | Characterizing visual fields in RPGR related retinitis pigmentosa using octopus static-automated perimetry |
| title_fullStr | Characterizing visual fields in RPGR related retinitis pigmentosa using octopus static-automated perimetry |
| title_full_unstemmed | Characterizing visual fields in RPGR related retinitis pigmentosa using octopus static-automated perimetry |
| title_short | Characterizing visual fields in RPGR related retinitis pigmentosa using octopus static-automated perimetry |
| title_sort | characterizing visual fields in rpgr related retinitis pigmentosa using octopus static automated perimetry |
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