Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes

Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes

<p>MHC-E regulates NK cells by displaying MHC class Ia signal peptides (VL9) to NKG2A:CD94 receptors. MHC-E can also present sequence-diverse, lower-affinity, pathogen-derived peptides to T cell receptors (TCRs) on CD8<sup>+</sup> T cells. To understand t...

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Detalhes bibliográficos
Principais autores:	Walters, LC, Rozbesky, D, Harlos, K, Quastel, M, Sun, H, Springer, S, Rambo, RP, Mohammed, F, Jones, EY, McMichael, AJ, Gillespie, GM
Formato:	Journal article
Idioma:	English
Publicado em:	Cell Press 2022

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