Ta1, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody.
By using a murine monoclonal antibody produced against an IL 2-dependent human T cell line, we defined a T lineage-specific molecule, termed Ta1, that is expressed strongly on activated T lymphocytes of both the T4 and T8 subsets, as well as on T cell lines and clones, but only weakly on a fraction...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1984
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| _version_ | 1797090124279840768 |
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| author | Fox, D Hussey, R Fitzgerald, K Acuto, O Poole, C Palley, L Daley, J Schlossman, S Reinherz, E |
| author_facet | Fox, D Hussey, R Fitzgerald, K Acuto, O Poole, C Palley, L Daley, J Schlossman, S Reinherz, E |
| author_sort | Fox, D |
| collection | OXFORD |
| description | By using a murine monoclonal antibody produced against an IL 2-dependent human T cell line, we defined a T lineage-specific molecule, termed Ta1, that is expressed strongly on activated T lymphocytes of both the T4 and T8 subsets, as well as on T cell lines and clones, but only weakly on a fraction of resting T cells. SDS-PAGE analysis of immunoprecipitates from 125I-labeled, activated T cells demonstrates a single major band of apparent m.w. 105 KD under both reducing and nonreducing conditions. Unlike anti-IL 2 receptor antibodies, anti-Ta1 does not inhibit T cell proliferative responses to mitogen, antigen, or IL 2-containing medium. Moreover, anti-Ta1 has no effect on T cell-mediated cytotoxicity. Ta1 appears to be a novel human T cell-specific activation antigen that may serve as a useful marker of T cell activation in human disease. |
| first_indexed | 2024-03-07T03:14:00Z |
| format | Journal article |
| id | oxford-uuid:b52a2de7-fd26-4ca3-b108-093ec5dae0c9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:14:00Z |
| publishDate | 1984 |
| record_format | dspace |
| spelling | oxford-uuid:b52a2de7-fd26-4ca3-b108-093ec5dae0c92022-03-27T04:31:29ZTa1, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b52a2de7-fd26-4ca3-b108-093ec5dae0c9EnglishSymplectic Elements at Oxford1984Fox, DHussey, RFitzgerald, KAcuto, OPoole, CPalley, LDaley, JSchlossman, SReinherz, EBy using a murine monoclonal antibody produced against an IL 2-dependent human T cell line, we defined a T lineage-specific molecule, termed Ta1, that is expressed strongly on activated T lymphocytes of both the T4 and T8 subsets, as well as on T cell lines and clones, but only weakly on a fraction of resting T cells. SDS-PAGE analysis of immunoprecipitates from 125I-labeled, activated T cells demonstrates a single major band of apparent m.w. 105 KD under both reducing and nonreducing conditions. Unlike anti-IL 2 receptor antibodies, anti-Ta1 does not inhibit T cell proliferative responses to mitogen, antigen, or IL 2-containing medium. Moreover, anti-Ta1 has no effect on T cell-mediated cytotoxicity. Ta1 appears to be a novel human T cell-specific activation antigen that may serve as a useful marker of T cell activation in human disease. |
| spellingShingle | Fox, D Hussey, R Fitzgerald, K Acuto, O Poole, C Palley, L Daley, J Schlossman, S Reinherz, E Ta1, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody. |
| title | Ta1, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody. |
| title_full | Ta1, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody. |
| title_fullStr | Ta1, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody. |
| title_full_unstemmed | Ta1, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody. |
| title_short | Ta1, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody. |
| title_sort | ta1 a novel 105 kd human t cell activation antigen defined by a monoclonal antibody |
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