Antigen processing defects in cervical carcinomas limit the presentation of a CTL epitope from human papillomavirus 16 E6.
Human papillomavirus (HPV) infection, particularly type 16, is causally associated with the development of cervical cancer. The E6 and E7 proteins of HPV are constitutively expressed in cervical carcinoma cells making them attractive targets for CTL-based immunotherapy. However, few studies have add...
Main Authors: | Evans, M, Borysiewicz, L, Evans, A, Rowe, M, Jones, M, Gileadi, U, Cerundolo, V, Man, S |
---|---|
Format: | Journal article |
Language: | English |
Published: |
2001
|
Similar Items
-
Use of fluorogenic histocompatibility leukocyte antigen-A*0201/HPV 16 E7 peptide complexes to isolate rare human cytotoxic T-lymphocyte-recognizing endogenous human papillomavirus antigens.
by: Youde, S, et al.
Published: (2000) -
Generation of an immunodominant CTL epitope is affected by proteasome subunit composition and stability of the antigenic protein.
by: Gileadi, U, et al.
Published: (1999) -
Role of the proteasome and non proteasomal proteases in the generation of CTL epitopes.
by: Cerundolo, V, et al.
Published: (1998) -
CTL epitope escape and reversion in acute HCV infection.
by: Timm, J, et al.
Published: (2004) -
Recombinant modified vaccinia Ankara primes functionally activated CTL specific for a melanoma tumor antigen epitope in melanoma patients with a high risk of disease recurrence.
by: Smith, C, et al.
Published: (2005)