The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair

The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair

Double-strand breaks (DSBs) are critical DNA lesions that robustly activate the elaborate DNA damage response (DDR) network. We identified a critical player in DDR fine-tuning: the E3/E4 ubiquitin ligase UBE4A. UBE4A's recruitment to sites of DNA damage is dependent on primary E3 ligases in the...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Baranes-Bachar, K, Levy-Barda, A, Oehler, J, Reid, D, Soria-Bretones, I, Voss, T, Chung, D, Park, Y, Liu, C, Yoon, J, Li, W, Dellaire, G, Misteli, T, Huertas, P, Rothenberg, E, Ramadan, K, Ziv, Y, Shiloh, Y
Fformat: Journal article
Iaith:English
Cyhoeddwyd: Cell Press 2018

Eitemau Tebyg