Evolution of the calcium-based intracellular signaling system
<p>To progress our understanding of molecular evolution from a collection of well-studied genes toward the level of the cell, we must consider whole systems. Here, we reveal the evolution of an important intracellular signaling system. The calcium-signaling toolkit is made up of different mul...
| Main Authors: | , , , , , |
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| Format: | Journal article |
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Oxford University Press
2016
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| _version_ | 1797090163688472576 |
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| author | Marchadier, E Oates, M Fang, H Donoghue, P Hetherington, A Gough, J |
| author_facet | Marchadier, E Oates, M Fang, H Donoghue, P Hetherington, A Gough, J |
| author_sort | Marchadier, E |
| collection | OXFORD |
| description | <p>To progress our understanding of molecular evolution from a collection of well-studied genes toward the level of the cell, we must consider whole systems. Here, we reveal the evolution of an important intracellular signaling system. The calcium-signaling toolkit is made up of different multidomain proteins that have undergone duplication, recombination, sequence divergence, and selection. The picture of evolution, considering the repertoire of proteins in the toolkit of both extant organisms and ancestors, is radically different from that of other systems. In eukaryotes, the repertoire increased in both abundance and diversity at a far greater rate than general genomic expansion. We describe how calcium-based intracellular signaling evolution differs not only in rate but in nature, and how this correlates with the disparity of plants and animals.</p> |
| first_indexed | 2024-03-07T03:14:34Z |
| format | Journal article |
| id | oxford-uuid:b55a780c-4756-42ad-a2b3-ba6f8ab3158b |
| institution | University of Oxford |
| last_indexed | 2024-03-07T03:14:34Z |
| publishDate | 2016 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:b55a780c-4756-42ad-a2b3-ba6f8ab3158b2022-03-27T04:32:51ZEvolution of the calcium-based intracellular signaling systemJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b55a780c-4756-42ad-a2b3-ba6f8ab3158bSymplectic Elements at OxfordOxford University Press2016Marchadier, EOates, MFang, HDonoghue, PHetherington, AGough, J <p>To progress our understanding of molecular evolution from a collection of well-studied genes toward the level of the cell, we must consider whole systems. Here, we reveal the evolution of an important intracellular signaling system. The calcium-signaling toolkit is made up of different multidomain proteins that have undergone duplication, recombination, sequence divergence, and selection. The picture of evolution, considering the repertoire of proteins in the toolkit of both extant organisms and ancestors, is radically different from that of other systems. In eukaryotes, the repertoire increased in both abundance and diversity at a far greater rate than general genomic expansion. We describe how calcium-based intracellular signaling evolution differs not only in rate but in nature, and how this correlates with the disparity of plants and animals.</p> |
| spellingShingle | Marchadier, E Oates, M Fang, H Donoghue, P Hetherington, A Gough, J Evolution of the calcium-based intracellular signaling system |
| title | Evolution of the calcium-based intracellular signaling system |
| title_full | Evolution of the calcium-based intracellular signaling system |
| title_fullStr | Evolution of the calcium-based intracellular signaling system |
| title_full_unstemmed | Evolution of the calcium-based intracellular signaling system |
| title_short | Evolution of the calcium-based intracellular signaling system |
| title_sort | evolution of the calcium based intracellular signaling system |
| work_keys_str_mv | AT marchadiere evolutionofthecalciumbasedintracellularsignalingsystem AT oatesm evolutionofthecalciumbasedintracellularsignalingsystem AT fangh evolutionofthecalciumbasedintracellularsignalingsystem AT donoghuep evolutionofthecalciumbasedintracellularsignalingsystem AT hetheringtona evolutionofthecalciumbasedintracellularsignalingsystem AT goughj evolutionofthecalciumbasedintracellularsignalingsystem |